TY  - JOUR
AU  - Roder, Constantin
AU  - Stummer, Walter
AU  - Coburger, Jan
AU  - Scherer, Moritz
AU  - Haas, Patrick
AU  - von der Brelie, Christian
AU  - Kamp, Marcel Alexander
AU  - Löhr, Mario
AU  - Hamisch, Christina A
AU  - Skardelly, Marco
AU  - Scholz, Torben
AU  - Schipmann, Stephanie
AU  - Rathert, Julian
AU  - Brand, Catrin Marlene
AU  - Pala, Andrej
AU  - Ernemann, Ulrike
AU  - Stockhammer, Florian
AU  - Gerlach, Rüdiger
AU  - Kremer, Paul
AU  - Goldbrunner, Roland
AU  - Ernestus, Ralf-Ingo
AU  - Sabel, Michael
AU  - Rohde, Veit
AU  - Tabatabai, Ghazaleh
AU  - Martus, Peter
AU  - Bisdas, Sotirios
AU  - Ganslandt, Oliver
AU  - Unterberg, Andreas
AU  - Wirtz, Christian Rainer
AU  - Tatagiba, Marcos
TI  - Intraoperative MRI-Guided Resection Is Not Superior to 5-Aminolevulinic Acid Guidance in Newly Diagnosed Glioblastoma: A Prospective Controlled Multicenter Clinical Trial.
JO  - Journal of clinical oncology
VL  - 41
IS  - 36
SN  - 0732-183X
CY  - Alexandria, Va.
PB  - American Society of Clinical Oncology
M1  - DKFZ-2023-01221
SP  - 5512-5523
PY  - 2023
N1  - 2023 Dec 20;41(36):5512-5523
AB  - Prospective data suggested a superiority of intraoperative MRI (iMRI) over 5-aminolevulinic acid (5-ALA) for achieving complete resections of contrast enhancement in glioblastoma surgery. We investigated this hypothesis in a prospective clinical trial and correlated residual disease volumes with clinical outcome in newly diagnosed glioblastoma.This is a prospective controlled multicenter parallel-group trial with two center-specific treatment arms (5-ALA and iMRI) and blinded evaluation. The primary end point was complete resection of contrast enhancement on early postoperative MRI. We assessed resectability and extent of resection by an independent blinded centralized review of preoperative and postoperative MRI with 1-mm slices. Secondary end points included progression-free survival (PFS) and overall survival (OS), patient-reported quality of life, and clinical parameters.We recruited 314 patients with newly diagnosed glioblastomas at 11 German centers. A total of 127 patients in the 5-ALA and 150 in the iMRI arm were analyzed in the as-treated analysis. Complete resections, defined as a residual tumor ≤0.175 cm³, were achieved in 90 patients (78
LB  - PUB:(DE-HGF)16
C6  - pmid:37335962
DO  - DOI:10.1200/JCO.22.01862
UR  - https://inrepo02.dkfz.de/record/276944
ER  -