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@ARTICLE{Ratliff:276945,
      author       = {M. Ratliff$^*$ and K. Karimian-Jazi$^*$ and D. C.
                      Hoffmann$^*$ and L. Rauschenbach and M. Simon and L. Hai$^*$
                      and H. Mandelbaum$^*$ and M. C. Schubert$^*$ and T.
                      Kessler$^*$ and S. Uhlig and D. D. Azorin$^*$ and E.
                      Jung$^*$ and M. Osswald$^*$ and G. M. Solecki$^*$ and M. E.
                      Maros and V. Venkataramani$^*$ and M. Glas$^*$ and N.
                      Etminan and B. Scheffler$^*$ and W. Wick$^*$ and F.
                      Winkler$^*$},
      title        = {{I}ndividual glioblastoma cells harbor both proliferative
                      and invasive capabilities during tumor progression.},
      journal      = {Neuro-Oncology},
      volume       = {25},
      number       = {12},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2023-01222},
      pages        = {2150-2162},
      year         = {2023},
      note         = {#EA:B320#LA:B320# / 2023 Dec 8;25(12):2150-2162},
      abstract     = {Glioblastomas are characterized by aggressive and
                      infiltrative growth, and by striking heterogeneity. The aim
                      of this study was to investigate whether tumor cell
                      proliferation and invasion are interrelated, or rather
                      distinct features of different cell populations.Tumor cell
                      invasion and proliferation was longitudinally determined in
                      real time using 3D in vivo two-photon laser scanning
                      microscopy over weeks. Glioblastoma cells expressed
                      fluorescent markers that permitted the identification of
                      their mitotic history or their cycling versus non-cycling
                      cell state.Live reporter systems were established that
                      allowed to dynamically determine the invasive behavior, and
                      previous or actual proliferation of distinct glioblastoma
                      cells, in different tumor regions and disease stages over
                      time. Particularly invasive tumor cells that migrated far
                      away from the main tumor mass, when followed over weeks, had
                      a history of marked proliferation and maintained their
                      proliferative capacity during brain colonization.
                      Infiltrating cells showed fewer connections to the
                      multicellular tumor cell network, a typical feature of
                      gliomas. Once tumor cells colonized a new brain region,
                      their phenotype progressively transitioned into tumor
                      microtube-rich, interconnected, slower-cycling glioblastoma
                      cells. Analysis of resected human glioblastomas confirmed a
                      higher proliferative potential of tumor cells from the
                      invasion zone.The detection of glioblastoma cells that
                      harbor both particularly high proliferative and invasive
                      capabilities during brain tumor progression provides
                      valuable insights into the interrelatedness of proliferation
                      and migration - two central traits of malignancy in glioma.
                      This contributes to our understanding how the brain is
                      efficiently colonized in this disease.},
      keywords     = {Glioblastoma (Other) / cancer neuroscience (Other) /
                      migration (Other) / proliferation (Other) / tumor microtubes
                      (TMs) (Other)},
      cin          = {B320 / HD01 / ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)ED01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37335907},
      doi          = {10.1093/neuonc/noad109},
      url          = {https://inrepo02.dkfz.de/record/276945},
}