%0 Journal Article
%A Sha, Sha
%A Gwenzi, Tafirenyika
%A Chen, Li-Ju
%A Brenner, Hermann
%A Schöttker, Ben
%T About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants.
%J European journal of epidemiology
%V 38
%N 9
%@ 0393-2990
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V.
%M DKFZ-2023-01223
%P 957-971
%D 2023
%Z #EA:C070#LA:C070# / 2023 Sep;38(9):957-971
%X It is unknown whether the well-known association between vitamin D deficiency and mortality could be explained by the immune system modulating effects of vitamin D, which may protect from a systemic inflammatory response (SIR) to adverse health conditions. This study aims to investigate the interrelationships of vitamin D deficiency, biomarkers of SIR, and mortality. We used multivariate logistic regression with adjustment for 51 covariates to assess the associations of vitamin D deficiency with disadvantageous levels of nine biomarkers of SIR in the UK Biobank cohort. Furthermore, we tested with Cox regression and mediation analysis whether biomarkers of SIR and vitamin D deficiency were independently associated with mortality. We included 397,737 participants aged 37-73 years. Vitamin D deficiency was associated with disadvantageous levels of all blood cell count-based biomarkers, but not with C-reactive protein (CRP)-based biomarkers after adjustment for body weight. Vitamin D deficiency and all biomarkers of SIR were significantly associated with all-cause mortality and mortality from cancer, cardiovascular and respiratory disease. The strength of these associations was unaltered if vitamin D deficiency and biomarkers of SIR were put in the same model. This finding was further supported by the mediation analyses. This study showed that vitamin D deficiency is associated with disadvantageous levels of blood cell count-based but not CRP-based biomarkers of SIR. Vitamin D deficiency and systemic inflammation were independently and strongly associated with mortality. The potential of clinical interventions against both vitamin D deficiency and underlying causes of systemic inflammation should be explored.
%K All-cause mortality (Other)
%K Cancer mortality (Other)
%K Cardiovascular mortality (Other)
%K Systemic inflammatory response (Other)
%K Vitamin D (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37340242
%R 10.1007/s10654-023-01023-2
%U https://inrepo02.dkfz.de/record/276946