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@ARTICLE{Sha:276946,
      author       = {S. Sha$^*$ and T. Gwenzi$^*$ and L.-J. Chen$^*$ and H.
                      Brenner$^*$ and B. Schöttker$^*$},
      title        = {{A}bout the associations of vitamin {D} deficiency and
                      biomarkers of systemic inflammatory response with all-cause
                      and cause-specific mortality in a general population sample
                      of almost 400,000 {UK} {B}iobank participants.},
      journal      = {European journal of epidemiology},
      volume       = {38},
      number       = {9},
      issn         = {0393-2990},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2023-01223},
      pages        = {957-971},
      year         = {2023},
      note         = {#EA:C070#LA:C070# / 2023 Sep;38(9):957-971},
      abstract     = {It is unknown whether the well-known association between
                      vitamin D deficiency and mortality could be explained by the
                      immune system modulating effects of vitamin D, which may
                      protect from a systemic inflammatory response (SIR) to
                      adverse health conditions. This study aims to investigate
                      the interrelationships of vitamin D deficiency, biomarkers
                      of SIR, and mortality. We used multivariate logistic
                      regression with adjustment for 51 covariates to assess the
                      associations of vitamin D deficiency with disadvantageous
                      levels of nine biomarkers of SIR in the UK Biobank cohort.
                      Furthermore, we tested with Cox regression and mediation
                      analysis whether biomarkers of SIR and vitamin D deficiency
                      were independently associated with mortality. We included
                      397,737 participants aged 37-73 years. Vitamin D deficiency
                      was associated with disadvantageous levels of all blood cell
                      count-based biomarkers, but not with C-reactive protein
                      (CRP)-based biomarkers after adjustment for body weight.
                      Vitamin D deficiency and all biomarkers of SIR were
                      significantly associated with all-cause mortality and
                      mortality from cancer, cardiovascular and respiratory
                      disease. The strength of these associations was unaltered if
                      vitamin D deficiency and biomarkers of SIR were put in the
                      same model. This finding was further supported by the
                      mediation analyses. This study showed that vitamin D
                      deficiency is associated with disadvantageous levels of
                      blood cell count-based but not CRP-based biomarkers of SIR.
                      Vitamin D deficiency and systemic inflammation were
                      independently and strongly associated with mortality. The
                      potential of clinical interventions against both vitamin D
                      deficiency and underlying causes of systemic inflammation
                      should be explored.},
      keywords     = {All-cause mortality (Other) / Cancer mortality (Other) /
                      Cardiovascular mortality (Other) / Systemic inflammatory
                      response (Other) / Vitamin D (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37340242},
      doi          = {10.1007/s10654-023-01023-2},
      url          = {https://inrepo02.dkfz.de/record/276946},
}