TY  - JOUR
AU  - King, Sontoria D
AU  - Veliginti, Swathi
AU  - Brouwers, Martijn C G J
AU  - Ren, Zhewen
AU  - Zheng, Wei
AU  - Setiawan, Veronica Wendy
AU  - Wilkens, Lynne R
AU  - Shu, Xiao-Ou
AU  - Arslan, Alan A
AU  - Beane Freeman, Laura E
AU  - Bracci, Paige M
AU  - Canzian, Federico
AU  - Du, Mengmeng
AU  - Gallinger, Steven J
AU  - Giles, Graham G
AU  - Goodman, Phyllis J
AU  - Haiman, Christopher A
AU  - Kogevinas, Manolis
AU  - Kooperberg, Charles
AU  - Le Marchand, Loic
AU  - Neale, Rachel E
AU  - Visvanathan, Kala
AU  - White, Emily
AU  - Albanes, Demetrius
AU  - Andreotti, Gabriella
AU  - Babic, Ana
AU  - Berndt, Sonja I
AU  - Brais, Lauren K
AU  - Brennan, Paul
AU  - Buring, Julie E
AU  - Rabe, Kari G
AU  - Bamlet, William R
AU  - Chanock, Stephen J
AU  - Fuchs, Charles S
AU  - Gaziano, J Michael
AU  - Giovannucci, Edward L
AU  - Hackert, Thilo
AU  - Hassan, Manal M
AU  - Katzke, Verena
AU  - Kurtz, Robert C
AU  - Lee, I-Min
AU  - Malats, Nuria
AU  - Murphy, Neil
AU  - Oberg, Ann L
AU  - Orlow, Irene
AU  - Porta, Miquel
AU  - Real, Francisco X
AU  - Rothman, Nathaniel
AU  - Sesso, Howard D
AU  - Silverman, Debra T
AU  - Thompson, Ian M
AU  - Wactawski-Wende, Jean
AU  - Wang, Xiaoliang
AU  - Wentzensen, Nicolas
AU  - Yu, Herbert
AU  - Zeleniuch-Jacquotte, Anne
AU  - Yu, Kai
AU  - Wolpin, Brian M
AU  - Duell, Eric J
AU  - Li, Donghui
AU  - Hung, Rayjean J
AU  - Perdomo, Sandra
AU  - McCullough, Marjorie L
AU  - Freedman, Neal D
AU  - Patel, Alpa V
AU  - Peters, Ulrike
AU  - Riboli, Elio
AU  - Sund, Malin
AU  - Tjønneland, Anne
AU  - Zhong, Jun
AU  - Van Den Eeden, Stephen K
AU  - Kraft, Peter
AU  - Risch, Harvey A
AU  - Amundadottir, Laufey T
AU  - Klein, Alison P
AU  - Stolzenberg-Solomon, Rachael Z
AU  - Antwi, Samuel O
TI  - Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 32
IS  - 9
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2023-01267
SP  - 1265-1269
PY  - 2023
N1  - 2023 Sep 1;32(9):1265-1269
AB  - There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer (PC). Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for PC.Data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium (PanScan; cases n=5090, controls n=8733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n=4,163, controls n=3,792) were analyzed. We used data on 68 genetic variants with four different MR methods (inverse variance weighting [IVW], MR-Egger, simple median, and penalized weighted median) separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and PC risk, using logistic regression to calculate odds ratios (ORs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:37351909
DO  - DOI:10.1158/1055-9965.EPI-23-0453
UR  - https://inrepo02.dkfz.de/record/277102
ER  -