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@ARTICLE{Decker:277106,
      author       = {N. S. Decker$^*$ and T. Johnson$^*$ and S. Behrens$^*$ and
                      N. Obi and R. Kaaks$^*$ and J. Chang-Claude$^*$ and R.
                      Turzanski-Fortner$^*$},
      title        = {{E}ndogenous estrogen receptor modulating oxysterols and
                      breast cancer prognosis: {R}esults from the {MARIE} patient
                      cohort.},
      journal      = {British journal of cancer},
      volume       = {129},
      number       = {3},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-01271},
      pages        = {492-502},
      year         = {2023},
      note         = {#EA:C020#LA:C020# / 2023 Aug;129(3):492-502},
      abstract     = {27-hydroxycholesterol (HC) and 25-HC were identified as
                      endogenous selective estrogen receptor modulators (SERMs)
                      and estrogen receptor (ER) modulators, respectively. They
                      are hypothesized to play a role in multiple physiologic
                      processes and pathologies, including breast cancer
                      development and progression.We evaluated circulating 27-HC
                      and 25-HC, and outcomes following a breast cancer diagnosis
                      in 2282 women from the MARIE study over median follow-up of
                      11.6 years. 27-HC and 25-HC were quantified by liquid
                      chromatography-mass spectrometry. We calculated hazard
                      ratios (HR) and $95\%$ confidence intervals [CI] using
                      multivariable Cox Proportional Hazards regression.We
                      observed no associations between 27-HC and breast cancer
                      prognosis overall. Associations between 27-HC and survival
                      differed by circulating estradiol concentrations and
                      endocrine therapy, but not by hormone receptor status. Among
                      women with estradiol levels below the median (0.08 nM),
                      27-HC was associated with higher risk of all-cause mortality
                      (HRlog2 = 1.80 [1.20-2.71]) and breast cancer-specific
                      mortality (HRlog2 = 1.95 [1.14-3.31]). No associations were
                      observed in women with estradiol levels above the median.
                      Higher 25-HC levels were associated with lower risk of
                      recurrence (HRlog2 = 0.87 [0.77-0.98]).Associations between
                      27-HC and breast cancer prognosis varied by circulating
                      estradiol levels and endocrine therapy. Less consistent
                      results were observed for 25-HC.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37355720},
      doi          = {10.1038/s41416-023-02315-w},
      url          = {https://inrepo02.dkfz.de/record/277106},
}