Home > Publications database > Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses. > print

001     277118
005     20240229155011.0
024 7 _ |a 10.1038/s41416-023-02312-z
|2 doi
024 7 _ |a pmid:37365285
|2 pmid
024 7 _ |a 0007-0920
|2 ISSN
024 7 _ |a 1532-1827
|2 ISSN
024 7 _ |a altmetric:150586658
|2 altmetric
037 _ _ |a DKFZ-2023-01283
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Dimou, Niki
|0 0000-0003-1678-9328
|b 0
245 _ _ |a Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
260 _ _ |a Edinburgh
|c 2023
|b Nature Publ. Group
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1691479560_28794
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a 2023 Aug;129(3):511-520
520 _ _ |a Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - ORAA: 1.62, 95% CI: 1.34-1.96; ORAG: 1.41, 95% CI: 1.30-1.54; ORGG: 1.22, 95% CI: 1.13-1.31; p-value3-d.f.: 5.46 × 10-11) and 13q14.13 (rs9526201, LRCH1 - ORGG: 2.11, 95% CI: 1.56-2.83; ORGA: 1.52, 95% CI: 1.38-1.68; ORAA: 1.13, 95% CI: 1.06-1.21; p-value2-d.f.: 7.84 × 10-09).These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
536 _ _ |a 313 - Krebsrisikofaktoren und Prävention (POF4-313)
|0 G:(DE-HGF)POF4-313
|c POF4-313
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
700 1 _ |a Kim, Andre E
|b 1
700 1 _ |a Flanagan, Orlagh
|b 2
700 1 _ |a Murphy, Neil
|0 0000-0003-3347-8249
|b 3
700 1 _ |a Diez-Obrero, Virginia
|b 4
700 1 _ |a Shcherbina, Anna
|b 5
700 1 _ |a Aglago, Elom K
|0 0000-0002-0442-3284
|b 6
700 1 _ |a Bouras, Emmanouil
|0 0000-0003-1489-5506
|b 7
700 1 _ |a Campbell, Peter T
|b 8
700 1 _ |a Casey, Graham
|b 9
700 1 _ |a Gallinger, Steven
|b 10
700 1 _ |a Gruber, Stephen B
|b 11
700 1 _ |a Jenkins, Mark A
|b 12
700 1 _ |a Lin, Yi
|b 13
700 1 _ |a Moreno, Victor
|0 0000-0002-2818-5487
|b 14
700 1 _ |a Ruiz-Narvaez, Edward
|0 0000-0002-0339-5824
|b 15
700 1 _ |a Stern, Mariana C
|b 16
700 1 _ |a Tian, Yu
|0 P:(DE-He78)834e8bc4d74592e3b999100c157215f5
|b 17
700 1 _ |a Tsilidis, Kostas K
|b 18
700 1 _ |a Arndt, Volker
|0 P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0
|b 19
|u dkfz
700 1 _ |a Barry, Elizabeth L
|b 20
700 1 _ |a Baurley, James W
|b 21
700 1 _ |a Berndt, Sonja I
|b 22
700 1 _ |a Bézieau, Stéphane
|b 23
700 1 _ |a Bien, Stephanie A
|b 24
700 1 _ |a Bishop, D Timothy
|0 0000-0002-8752-8785
|b 25
700 1 _ |a Brenner, Hermann
|0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2
|b 26
|u dkfz
700 1 _ |a Budiarto, Arif
|b 27
700 1 _ |a Carreras-Torres, Robert
|b 28
700 1 _ |a Cenggoro, Tjeng Wawan
|b 29
700 1 _ |a Chan, Andrew T
|0 0000-0001-7284-6767
|b 30
700 1 _ |a Chang-Claude, Jenny
|0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253
|b 31
|u dkfz
700 1 _ |a Chanock, Stephen J
|b 32
700 1 _ |a Chen, Xuechen
|0 P:(DE-He78)c392ec8a090dcfbe801f135a6212caf9
|b 33
|u dkfz
700 1 _ |a Conti, David V
|b 34
700 1 _ |a Dampier, Christopher H
|b 35
700 1 _ |a Devall, Matthew
|b 36
700 1 _ |a Drew, David A
|b 37
700 1 _ |a Figueiredo, Jane C
|b 38
700 1 _ |a Giles, Graham G
|b 39
700 1 _ |a Gsur, Andrea
|b 40
700 1 _ |a Harrison, Tabitha A
|b 41
700 1 _ |a Hidaka, Akihisa
|b 42
700 1 _ |a Hoffmeister, Michael
|0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f
|b 43
|u dkfz
700 1 _ |a Huyghe, Jeroen R
|0 0000-0001-6027-9806
|b 44
700 1 _ |a Jordahl, Kristina
|b 45
700 1 _ |a Kawaguchi, Eric
|b 46
700 1 _ |a Keku, Temitope O
|b 47
700 1 _ |a Larsson, Susanna C
|0 0000-0003-0118-0341
|b 48
700 1 _ |a Le Marchand, Loic
|b 49
700 1 _ |a Lewinger, Juan Pablo
|b 50
700 1 _ |a Li, Li
|b 51
700 1 _ |a Mahesworo, Bharuno
|b 52
700 1 _ |a Morrison, John
|b 53
700 1 _ |a Newcomb, Polly A
|0 0000-0001-8786-0043
|b 54
700 1 _ |a Newton, Christina C
|b 55
700 1 _ |a Obon-Santacana, Mireia
|b 56
700 1 _ |a Ose, Jennifer
|b 57
700 1 _ |a Pai, Rish K
|b 58
700 1 _ |a Palmer, Julie R
|0 0000-0002-6534-335X
|b 59
700 1 _ |a Papadimitriou, Nikos
|b 60
700 1 _ |a Pardamean, Bens
|b 61
700 1 _ |a Peoples, Anita R
|b 62
700 1 _ |a Pharoah, Paul D P
|0 0000-0001-8494-732X
|b 63
700 1 _ |a Platz, Elizabeth A
|b 64
700 1 _ |a Potter, John D
|0 0000-0001-5439-1500
|b 65
700 1 _ |a Rennert, Gad
|b 66
700 1 _ |a Scacheri, Peter C
|b 67
700 1 _ |a Schoen, Robert E
|b 68
700 1 _ |a Su, Yu-Ru
|b 69
700 1 _ |a Tangen, Catherine M
|b 70
700 1 _ |a Thibodeau, Stephen N
|b 71
700 1 _ |a Thomas, Duncan C
|b 72
700 1 _ |a Ulrich, Cornelia M
|b 73
700 1 _ |a Um, Caroline Y
|0 0000-0001-5449-6230
|b 74
700 1 _ |a van Duijnhoven, Franzel J B
|b 75
700 1 _ |a Visvanathan, Kala
|0 0000-0002-0582-8005
|b 76
700 1 _ |a Vodicka, Pavel
|b 77
700 1 _ |a Vodickova, Ludmila
|b 78
700 1 _ |a White, Emily
|b 79
700 1 _ |a Wolk, Alicja
|0 0000-0001-7387-6845
|b 80
700 1 _ |a Woods, Michael O
|b 81
700 1 _ |a Qu, Conghui
|b 82
700 1 _ |a Kundaje, Anshul
|0 0000-0003-3084-2287
|b 83
700 1 _ |a Hsu, Li
|b 84
700 1 _ |a Gauderman, W James
|b 85
700 1 _ |a Gunter, Marc J
|b 86
700 1 _ |a Peters, Ulrike
|b 87
773 _ _ |a 10.1038/s41416-023-02312-z
|0 PERI:(DE-600)2002452-6
|n 3
|p 511-520
|t British journal of cancer
|v 129
|y 2023
|x 0007-0920
909 C O |p VDB
|o oai:inrepo02.dkfz.de:277118
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 17
|6 P:(DE-He78)834e8bc4d74592e3b999100c157215f5
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 19
|6 P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 26
|6 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 31
|6 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 33
|6 P:(DE-He78)c392ec8a090dcfbe801f135a6212caf9
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 43
|6 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-313
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Krebsrisikofaktoren und Prävention
|x 0
914 1 _ |y 2023
915 _ _ |a DEAL Springer
|0 StatID:(DE-HGF)3002
|2 StatID
|d 2022-11-15
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2022-11-15
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2022-11-15
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2022-11-15
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
|d 2023-10-22
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b BRIT J CANCER : 2022
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2023-10-22
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2023-10-22
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b BRIT J CANCER : 2022
|d 2023-10-22
920 1 _ |0 I:(DE-He78)C020-20160331
|k C020
|l C020 Epidemiologie von Krebs
|x 0
920 1 _ |0 I:(DE-He78)C070-20160331
|k C070
|l C070 Klinische Epidemiologie und Alternf.
|x 1
920 1 _ |0 I:(DE-He78)C120-20160331
|k C120
|l Präventive Onkologie
|x 2
920 1 _ |0 I:(DE-He78)HD01-20160331
|k HD01
|l DKTK HD zentral
|x 3
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)C020-20160331
980 _ _ |a I:(DE-He78)C070-20160331
980 _ _ |a I:(DE-He78)C120-20160331
980 _ _ |a I:(DE-He78)HD01-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21