%0 Journal Article
%A Gwenzi, Tafirenyika
%A Schrotz-King, Petra
%A Schöttker, Ben
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Vitamin D Status, Cdx2 Genotype, and Colorectal Cancer Survival: Population-Based Patient Cohort.
%J Nutrients
%V 15
%N 12
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2023-01289
%P 2717
%D 2023
%Z #EA:C120#LA:C120#LA:C070#
%X According to recent evidence, the prognostic value of Vitamin D (VitD) status for colorectal cancer (CRC) patients might be confined to patients with the GG genotype of Cdx2, a functional polymorphism of the VitD receptor gene. We aimed to validate these findings in a cohort of CRC patients. Post-operative serum 25-hydroxyvitamin D concentration was determined by mass spectrometry and Cdx2 genotyping was performed from blood or buccal swabs using standard methods. Joint associations of VitD status and Cdx2 with overall survival (OS), CRC-specific survival (CSS), recurrence-free survival (RFS), and disease-free survival (DFS) were assessed using Cox regression. For patients with GG genotype, adjusted hazard ratios (95
%K colorectal cancer (Other)
%K genotype (Other)
%K survival (Other)
%K vitamin D receptor (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37375621
%R 10.3390/nu15122717
%U https://inrepo02.dkfz.de/record/277127