%0 Journal Article
%A Weissinger, Matthias
%A Atmanspacher, Max
%A Spengler, Werner
%A Seith, Ferdinand
%A Von Beschwitz, Sebastian
%A Dittmann, Helmut
%A Zender, Lars
%A Smith, Anne M
%A Casey, Michael E
%A Nikolaou, Konstantin
%A Castaneda-Vega, Salvador
%A la Fougère, Christian
%T Diagnostic Performance of Dynamic Whole-Body Patlak [18F]FDG-PET/CT in Patients with Indeterminate Lung Lesions and Lymph Nodes.
%J Journal of Clinical Medicine
%V 12
%N 12
%@ 2077-0383
%C Basel
%I MDPI
%M DKFZ-2023-01290
%P 3942
%D 2023
%X Static [18F]FDG-PET/CT is the imaging method of choice for the evaluation of indeterminate lung lesions and NSCLC staging; however, histological confirmation of PET-positive lesions is needed in most cases due to its limited specificity. Therefore, we aimed to evaluate the diagnostic performance of additional dynamic whole-body PET.A total of 34 consecutive patients with indeterminate pulmonary lesions were enrolled in this prospective trial. All patients underwent static (60 min p.i.) and dynamic (0-60 min p.i.) whole-body [18F]FDG-PET/CT (300 MBq) using the multi-bed-multi-timepoint technique (Siemens mCT FlowMotion). Histology and follow-up served as ground truth. Kinetic modeling factors were calculated using a two-compartment linear Patlak model (FDG influx rate constant = Ki, metabolic rate = MR-FDG, distribution volume = DV-FDG) and compared to SUV using ROC analysis.MR-FDGmean provided the best discriminatory power between benign and malignant lung lesions with an AUC of 0.887. The AUC of DV-FDGmean (0.818) and SUVmean (0.827) was non-significantly lower. For LNM, the AUCs for MR-FDGmean (0.987) and SUVmean (0.993) were comparable. Moreover, the DV-FDGmean in liver metastases was three times higher than in bone or lung metastases.Metabolic rate quantification was shown to be a reliable method to detect malignant lung tumors, LNM, and distant metastases at least as accurately as the established SUV or dual-time-point PET scans.
%K FDG (Other)
%K PET/CT (Other)
%K Patlak (Other)
%K dynamic PET (Other)
%K parametric FDG (Other)
%K whole-body (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37373636
%R 10.3390/jcm12123942
%U https://inrepo02.dkfz.de/record/277128