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@ARTICLE{Geissler:277129,
      author       = {M. Geissler and W. Jia and E. N. Kiraz and I. Kulacz and X.
                      Liu and A. Rombach and V. Prinz and D. Jussen and K. D.
                      Kokkaliaris$^*$ and H. Medyouf$^*$ and L. Sevenich$^*$ and
                      M. Czabanka and T. Broggini},
      title        = {{T}he {B}rain {P}re-{M}etastatic {N}iche: {B}iological and
                      {T}echnical {A}dvancements.},
      journal      = {International journal of molecular sciences},
      volume       = {24},
      number       = {12},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2023-01291},
      pages        = {10055},
      year         = {2023},
      abstract     = {Metastasis, particularly brain metastasis, continues to
                      puzzle researchers to this day, and exploring its molecular
                      basis promises to break ground in developing new strategies
                      for combatting this deadly cancer. In recent years, the
                      research focus has shifted toward the earliest steps in the
                      formation of metastasis. In this regard, significant
                      progress has been achieved in understanding how the primary
                      tumor affects distant organ sites before the arrival of
                      tumor cells. The term pre-metastatic niche was introduced
                      for this concept and encompasses all influences on sites of
                      future metastases, ranging from immunological modulation and
                      ECM remodeling to the softening of the blood-brain barrier.
                      The mechanisms governing the spread of metastasis to the
                      brain remain elusive. However, we begin to understand these
                      processes by looking at the earliest steps in the formation
                      of metastasis. This review aims to present recent findings
                      on the brain pre-metastatic niche and to discuss existing
                      and emerging methods to further explore the field. We begin
                      by giving an overview of the pre-metastatic and metastatic
                      niches in general before focusing on their manifestations in
                      the brain. To conclude, we reflect on the methods usually
                      employed in this field of research and discuss novel
                      approaches in imaging and sequencing.},
      subtyp        = {Review Article},
      keywords     = {advanced imaging (Other) / brain metastasis (Other) / brain
                      pre-metastatic niche (Other) / metastatic niche (Other) /
                      pre-metastatic niche (Other) / single-cell sequencing
                      (Other) / transcriptomics (Other) / vascular niche (Other)},
      cin          = {FM01},
      ddc          = {540},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37373202},
      doi          = {10.3390/ijms241210055},
      url          = {https://inrepo02.dkfz.de/record/277129},
}