% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Popp:277135,
      author       = {I. Popp$^*$ and N. E. Hartong$^*$ and C. Nieder and A.-L.
                      Grosu$^*$},
      title        = {{PRO}: {D}o {W}e {S}till {N}eed {W}hole-{B}rain
                      {I}rradiation for {B}rain {M}etastases?},
      journal      = {Cancers},
      volume       = {15},
      number       = {12},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01297},
      pages        = {3193},
      year         = {2023},
      abstract     = {(1) Background: In recent decades, the use of whole-brain
                      radiation therapy (WBRT) in the treatment of brain
                      metastases has significantly decreased, with clinicians
                      fearing adverse neurocognitive events and data showing
                      limited efficacy regarding local tumor control and overall
                      survival. The present study thus aimed to reassess the role
                      that WBRT holds in the treatment of brain metastases. (2)
                      Methods: This review summarizes the available evidence from
                      1990 until today supporting the use of WBRT, as well as new
                      developments in WBRT and their clinical implications. (3)
                      Results: While one to four brain metastases should be
                      exclusively treated with radiosurgery, WBRT does remain an
                      option for patients with multiple metastases. In particular,
                      hippocampus-avoidance WBRT, WBRT with dose escalation to the
                      metastases, and their combination have shown promising
                      results and offer valid alternatives to local stereotactic
                      radiotherapy. Ongoing and published prospective trials on
                      the efficacy and toxicity of these new methods are
                      presented. (4) Conclusions: Unlike conventional WBRT, which
                      has limited indications, modern WBRT techniques continue to
                      have a significant role to play in the treatment of multiple
                      brain metastases. In which situations radiosurgery or WBRT
                      should be the first option should be investigated in further
                      studies. Until then, the therapeutic decision must be made
                      individually depending on the oncological context.},
      subtyp        = {Review Article},
      keywords     = {WBRT (Other) / brain metastases (Other) / cognition (Other)
                      / hippocampus avoidance (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37370802},
      doi          = {10.3390/cancers15123193},
      url          = {https://inrepo02.dkfz.de/record/277135},
}