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@ARTICLE{Vlaski:277136,
      author       = {T. Vlaski$^*$ and M. Slavic$^*$ and R. Caspari and H.
                      Fischer and H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{D}evelopment {T}rajectories of {F}atigue, {Q}uality of
                      {L}ife, and the {A}bility to {W}ork among {C}olorectal
                      {C}ancer {P}atients in the {F}irst {Y}ear after
                      {R}ehabilitation-{F}irst {R}esults of the {MIRANDA}
                      {S}tudy.},
      journal      = {Cancers},
      volume       = {15},
      number       = {12},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01298},
      pages        = {3168},
      year         = {2023},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Cancer-related fatigue, low quality of life (QoL), and low
                      ability to work are highly prevalent among colorectal cancer
                      (CRC) patients after tumor surgery. We aimed to analyze
                      their intercorrelations and trajectories in the first year
                      after in-patient rehabilitation in the German multicenter
                      MIRANDA cohort study. Recruitment is ongoing, and we
                      included the first 147 CRC patients in this analysis.
                      Participants filled out questionnaires at the beginning of
                      in-patient rehabilitation (baseline) and at 3, 6, 9, and 12
                      months after the baseline. The
                      EORTC-QLQ-C30-General-Health-Status (GHS)/QoL, the
                      FACIT-F-Fatigue Scale, and the FACIT-F-FWB-ability-to-work
                      items were used to evaluate QoL, fatigue, and ability to
                      work, respectively. The fatigue and QoL scales were highly
                      correlated (r = 0.606). A moderate correlation was observed
                      between the fatigue and ability to work scales (r = 0.487)
                      and between the QoL and ability to work scales (r = 0.455).
                      Compared to the baseline, a statistically significant
                      improvement in the QoL, ability to work, and fatigue scales
                      were observed at the 3-month follow-up (Wilcoxson signed
                      rank test, all p < 0.0001). The three scales plateaued
                      afterward until the 12-month follow-up. In conclusion,
                      fatigue, QoL, and ability to work were highly interrelated,
                      improved quickly during/after in-patient rehabilitation, and
                      did not change much afterward in German CRC patients.},
      keywords     = {ability to work (Other) / colorectal cancer (Other) /
                      fatigue (Other) / quality of life (Other) / rehabilitation
                      (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37370777},
      doi          = {10.3390/cancers15123168},
      url          = {https://inrepo02.dkfz.de/record/277136},
}