%0 Journal Article
%A Sharma, Gitanjali
%A Braga, Marta C
%A Da Pieve, Chiara
%A Szopa, Wojciech
%A Starzetz, Tatjana
%A Plate, Karl H
%A Kaspera, Wojciech
%A Kramer-Marek, Gabriela
%T Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma.
%J Cancers
%V 15
%N 12
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2023-01299
%P 3131
%D 2023
%X There is no established method to assess the PD-L1 expression in brain tumours. Therefore, we investigated the suitability of affibody molecule (ZPD-L1) radiolabelled with F-18 (Al18F) and Ga-68 to measure the expression of PD-L1 in xenograft mouse models of GBM. Mice bearing subcutaneous and orthotopic tumours were imaged 1 h post-radioconjugate administration. Ex vivo biodistribution studies and immunohistochemistry (IHC) staining were performed. Tumoural PD-L1 expression and CD4+/CD8+ tumour-infiltrating lymphocytes were evaluated in human GBM specimens. ZPD-L1 was radiolabelled with radiochemical yields of 32.2 ± 4.4
%K PD-L1 (Other)
%K affibody molecule (Other)
%K glioblastoma (Other)
%K immuno-PET (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37370741
%R 10.3390/cancers15123131
%U https://inrepo02.dkfz.de/record/277137