TY  - JOUR
AU  - Sharma, Gitanjali
AU  - Braga, Marta C
AU  - Da Pieve, Chiara
AU  - Szopa, Wojciech
AU  - Starzetz, Tatjana
AU  - Plate, Karl H
AU  - Kaspera, Wojciech
AU  - Kramer-Marek, Gabriela
TI  - Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma.
JO  - Cancers
VL  - 15
IS  - 12
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-01299
SP  - 3131
PY  - 2023
AB  - There is no established method to assess the PD-L1 expression in brain tumours. Therefore, we investigated the suitability of affibody molecule (ZPD-L1) radiolabelled with F-18 (Al18F) and Ga-68 to measure the expression of PD-L1 in xenograft mouse models of GBM. Mice bearing subcutaneous and orthotopic tumours were imaged 1 h post-radioconjugate administration. Ex vivo biodistribution studies and immunohistochemistry (IHC) staining were performed. Tumoural PD-L1 expression and CD4+/CD8+ tumour-infiltrating lymphocytes were evaluated in human GBM specimens. ZPD-L1 was radiolabelled with radiochemical yields of 32.2 ± 4.4
KW  - PD-L1 (Other)
KW  - affibody molecule (Other)
KW  - glioblastoma (Other)
KW  - immuno-PET (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37370741
DO  - DOI:10.3390/cancers15123131
UR  - https://inrepo02.dkfz.de/record/277137
ER  -