%0 Journal Article
%A Fotouhi, Omid
%A Nizamuddin, Sheikh
%A Falk, Stephanie
%A Schilling, Oliver
%A Knüchel-Clarke, Ruth
%A Biniossek, Martin L
%A Timmers, Hermanus Theodorus Marcus
%T Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A.
%J Cancers
%V 15
%N 12
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2023-01300
%P 3117
%D 2023
%X The UTX/KDM6A histone H3K27 demethylase plays an important role in development and is frequently mutated in cancers such as urothelial cancer. Despite many studies on UTX proteins, variations in mRNA splicing have been overlooked. Using Nanopore sequencing, we present a comprehensive analysis of UTX/KDM6A splicing events in human cell lines and in tissue samples from bladder cancer cases and normal epithelia. We found that the central region of UTX mRNAs encoded by exons 12 to 17 undergoes extensive alternative splicing. Up to half of all stable mRNAs (8-48
%K alternative splicing (Other)
%K bladder cancer (Other)
%K cancer biology (Other)
%K chromatin (Other)
%K histone demethylase (Other)
%K histone methylation (Other)
%K proteomics (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37370727
%R 10.3390/cancers15123117
%U https://inrepo02.dkfz.de/record/277138