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@ARTICLE{Anker:277278,
      author       = {M. S. Anker and S. K. Potthoff and A. Lena and J. Porthun
                      and S. Hadzibegovic and R. Evertz and C. Denecke and A.-K.
                      Fröhlich and F. Sonntag and V. Regitz-Zagrosek and S. D.
                      Rosen and A. R. Lyon and T. F. Lüscher and J. A. Spertus
                      and S. D. Anker and M. Karakas and L. Bullinger$^*$ and U.
                      Keller$^*$ and U. Landmesser and J. Butler and S. von
                      Haehling},
      title        = {{C}ardiovascular health-related quality of life in cancer:
                      a prospective study comparing the {ESC} {H}eart{Q}o{L} and
                      {EORTC} {QLQ}-{C}30 questionnaire.},
      journal      = {European journal of heart failure},
      volume       = {25},
      number       = {9},
      issn         = {1388-9842},
      address      = {Oxford},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-01312},
      pages        = {1635-1647},
      year         = {2023},
      note         = {2023 Sep;25(9):1635-1647},
      abstract     = {Health-related quality of life (HRQoL) is highly relevant
                      in cancer and often assessed with the EORTC QLQ-C30.
                      Cardiovascular HRQoL in cancer can be measured with the ESC
                      HeartQoL questionnaire. We compared these instruments and
                      examined their prognostic value.Summary scores for EORTC
                      QLQ-C30 (0-100 points) and HeartQoL (0-3 points)
                      questionnaires were prospectively assessed in 290 patients
                      with mostly advanced cancer (stage 3/4: $81\%,$ 1-year
                      mortality: $36\%)$ and 50 healthy controls (similar age and
                      sex). Additionally, physical function and activity
                      assessments were performed.Both questionnaires demonstrated
                      reduced HRQoL in patients with cancer vs controls (EORTC
                      QLQ-C30: 67±20 vs 91±11, p<0.001; ESC HeartQoL: 1.8±0.8
                      vs 2.7±0.4, p<0.001). The instruments were strongly
                      correlated with each other (summary scores (r=0.76),
                      physical (r=0.81), and emotional subscales (r=0.75, all
                      p<0.001)) and independently associated with all-cause
                      mortality (best cut-offs: EORTC QLQ-C30 <82.69: hazard ratio
                      (HR) 2.33, p=0.004, HeartQoL <1.50: HR 1.85, p=0.004 -
                      adjusted for sex, age, left ventricular ejection fraction,
                      NT-proBNP, hsTroponinT, cancer stage/type), with no
                      differences in the strength of the association by sex
                      (p-interaction>0.9). Combining both questionnaires
                      identified three risk groups with highest mortality in
                      patients below both cut-offs (vs. patients above both
                      cut-offs: HR 3.60, p<0.001). Patients with results below
                      both cut-offs, showed higher NT-proBNP and reduced physical
                      function and activity.EORTC QLQ-C30 and ESC HeartQoL -
                      assessing cancer and cardiovascular HRQoL - are both
                      associated with increased mortality in cancer patients, with
                      even greater stratification by combing both. Reduced HRQoL
                      scores were associated with elevated cardiovascular
                      biomarkers and decreased functional status. This article is
                      protected by copyright. All rights reserved.},
      keywords     = {EORTC QLQ-C30 (Other) / HeartQoL (Other) / patients with
                      cancer (Other) / quality of life (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37369985},
      doi          = {10.1002/ejhf.2951},
      url          = {https://inrepo02.dkfz.de/record/277278},
}