%0 Journal Article
%A Ingwersen, Viktoria
%A Hofmann, Jörg
%A Muche, Marion
%A Le Coutre, Philipp
%A Schneider, Thomas
%A Leng, Corinna
%A Burmeister, Thomas
%A Maschmeyer, Georg
%A Keller, Ulrich
%A Schwartz, Stefan
%T Variable outcomes of hepatitis E infections in patients with hemato-oncologic diseases
%J Oncology research and treatment
%V 46
%N 7-8
%@ 2296-5270
%C Basel
%I Karger
%M DKFZ-2023-01329
%P 296-302
%D 2023
%Z 2023;46(7-8):296-302
%X Introduction.The hepatitis E virus (HEV) represents an important cause of viral hepatitis and could cause chronicinfections in immunocompromised patients. However, data about immunocompromised patientsother than solid organ transplant recipients are limited.Methods.We identified patients from a laboratory database and retrospectively compiled and analyzed clinicalas well as laboratory data in detail.ResultsOverall, 22 severely immunosuppressed patients, excluding solid organ transplant recipients, wereidentified. Four patients did not experience viral clearance (one without and three despite ribavirintherapy). Three patients acquired the infection after allogeneic hematopoietic stem celltransplantation (alloHSCT) and recovered spontaneously, whereas another patient, infected prior toalloHSCT, developed a chronic infection. Four patients failed to clear HEV, resulting in fatal liver failurein two patients. The CD4+ cell counts increased in all but one patient attaining a sustained virologicalresponse (SVR), as compared to patients with clinical failure. Severe immunoglobulin deficiency didnot appear to obviate the control of HEV. Six of ten (60
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37311423
%R 10.1159/000531538
%U https://inrepo02.dkfz.de/record/277311