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@ARTICLE{Gwenzi:277322,
      author       = {T. Gwenzi$^*$ and A. Zhu$^*$ and P. Schrotz-King$^*$ and B.
                      Schöttker$^*$ and M. Hoffmeister$^*$ and D. Edelmann$^*$
                      and H. Brenner$^*$},
      title        = {{P}rognostic {V}alue of {P}ost-{O}perative {C}-{R}eactive
                      {P}rotein-{B}ased {I}nflammatory {B}iomarkers in
                      {C}olorectal {C}ancer {P}atients: {S}ystematic {R}eview and
                      {M}eta-{A}nalysis.},
      journal      = {Clinical epidemiology},
      volume       = {15},
      issn         = {1179-1349},
      address      = {Albany, Auckland},
      publisher    = {Dove Medical Press},
      reportid     = {DKFZ-2023-01340},
      pages        = {795 - 809},
      year         = {2023},
      note         = {#EA:C120#LA:C120#LA:C070#},
      abstract     = {Post-operative inflammation in cancer patients can be
                      modulated by drugs and diets, but evidence on its prognostic
                      role, which would be crucial for personalized treatment and
                      surveillance schemes, remains rather limited. We aimed to
                      systematically review and meta-analyse studies on the
                      prognostic value of post-operative C-reactive protein
                      (CRP)-based inflammatory biomarkers among patients with
                      colorectal cancer (CRC) (PROSPERO#: CRD42022293832). PubMed,
                      Web of Science and Cochrane databases were searched until
                      February 2023. Studies reporting associations between
                      post-operative CRP, Glasgow Prognostic Score (GPS) or
                      modified Glasgow Prognostic Score (mGPS) with overall
                      survival (OS), CRC-specific survival (CSS) and
                      recurrence-free survival (RFS) were included. Hazard ratios
                      (HRs) with $95\%$ confidence intervals (CIs) for the
                      predictor-outcome associations were pooled using R-software,
                      version 4.2. Sixteen studies (n = 6079) were included in the
                      meta-analyses. Elevated post-operative CRP was a predictor
                      of poor OS, CSS and RFS compared with low CRP levels [HR
                      $(95\%$ CI): 1.72 (1.32-2.25); 1.63 (1.30-2.05); 2.23
                      (1.44-3.47), respectively]. A unit increase in
                      post-operative GPS predicted poor OS [HR $(95\%$ Cl): 1.31
                      (1.14-1.51)]. Moreover, a unit increase in post-operative
                      mGPS was associated with poor OS and CSS [HR $(95\%$ Cl):
                      1.93 (1.37-2.72); 3.16 (1.48-6.76), respectively].
                      Post-operative CRP-based inflammatory biomarkers have a
                      significant prognostic role for patients with CRC.
                      Prognostic value of these easy-to-obtain routine
                      measurements thereby seems to outperform most of the much
                      more complex blood- or tissue-based predictors in the
                      current focus of multi-omics-based research. Future studies
                      should validate our findings, establish optimal time for
                      biomarker assessment and determine clinically useful cut-off
                      values of these biomarkers for post-operative
                      risk-stratification and treatment-response monitoring.},
      subtyp        = {Review Article},
      keywords     = {C-reactive protein (Other) / assess (Other) /
                      risk-stratification (Other) / survival (Other) /
                      treatment-response (Other)},
      cin          = {C120 / C070 / C060 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37396024},
      pmc          = {pmc:PMC10314753},
      doi          = {10.2147/CLEP.S415171},
      url          = {https://inrepo02.dkfz.de/record/277322},
}