%0 Journal Article
%A Morra, Anna
%A Schreurs, Maartje A C
%A Andrulis, Irene L
%A Anton-Culver, Hoda
%A Augustinsson, Annelie
%A Beckmann, Matthias W
%A Behrens, Sabine
%A Bojesen, Stig E
%A Bolla, Manjeet K
%A Brauch, Hiltrud
%A Broeks, Annegien
%A Buys, Saundra S
%A Camp, Nicola J
%A Castelao, Jose E
%A Cessna, Melissa H
%A Chang-Claude, Jenny
%A Chung, Wendy K
%A Colonna, Sarah V
%A Couch, Fergus J
%A Cox, Angela
%A Cross, Simon S
%A Czene, Kamila
%A Daly, Mary B
%A Dennis, Joe
%A Devilee, Peter
%A Dörk, Thilo
%A Dunning, Alison M
%A Dwek, Miriam
%A Easton, Douglas F
%A Eccles, Diana M
%A Eriksson, Mikael
%A Evans, D Gareth
%A Fasching, Peter A
%A Fehm, Tanja N
%A Figueroa, Jonine D
%A Flyger, Henrik
%A Gabrielson, Marike
%A Gago-Dominguez, Manuela
%A García-Closas, Montserrat
%A García-Sáenz, José A
%A Genkinger, Jeanine
%A Grassmann, Felix
%A Gündert, Melanie
%A Hahnen, Eric
%A Haiman, Christopher A
%A Hamann, Ute
%A Harrington, Patricia A
%A Hartikainen, Jaana M
%A Hoppe, Reiner
%A Hopper, John L
%A Houlston, Richard S
%A Howell, Anthony
%A Jakubowska, Anna
%A Janni, Wolfgang
%A Jernström, Helena
%A John, Esther M
%A Johnson, Nichola
%A Jones, Michael E
%A Kristensen, Vessela N
%A Kurian, Allison W
%A Lambrechts, Diether
%A Le Marchand, Loic
%A Lindblom, Annika
%A Lubiński, Jan
%A Lux, Michael P
%A Mannermaa, Arto
%A Mavroudis, Dimitrios
%A Mulligan, Anna Marie
%A Muranen, Taru A
%A Nevanlinna, Heli
%A Nevelsteen, Ines
%A Neven, Patrick
%A Newman, William G
%A Obi, Nadia
%A Offit, Kenneth
%A Olshan, Andrew F
%A Park-Simon, Tjoung-Won
%A Patel, Alpa V
%A Peterlongo, Paolo
%A Phillips, Kelly-Anne
%A Plaseska-Karanfilska, Dijana
%A Polley, Eric C
%A Presneau, Nadege
%A Pylkäs, Katri
%A Rack, Brigitte
%A Radice, Paolo
%A Rashid, Muhammad U
%A Rhenius, Valerie
%A Robson, Mark
%A Romero, Atocha
%A Saloustros, Emmanouil
%A Sawyer, Elinor J
%A Schmutzler, Rita K
%A Schuetze, Sabine
%A Scott, Christopher
%A Shah, Mitul
%A Smichkoska, Snezhana
%A Southey, Melissa C
%A Tapper, William J
%A Teras, Lauren R
%A Tollenaar, Rob A E M
%A Tomczyk, Katarzyna
%A Tomlinson, Ian
%A Troester, Melissa A
%A Vachon, Celine M
%A van Veen, Elke M
%A Wang, Qin
%A Wendt, Camilla
%A Wildiers, Hans
%A Winqvist, Robert
%A Ziogas, Argyrios
%A Hall, Per
%A Pharoah, Paul D P
%A Adank, Muriel A
%A Hollestelle, Antoinette
%A Schmidt, Marjanka K
%A Hooning, Maartje J
%T Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.
%J Cancer medicine
%V 12
%N 15
%@ 2045-7634
%C Hoboken, NJ
%I Wiley
%M DKFZ-2023-01343
%P 16142-16162
%D 2023
%Z 2023 Aug;12(15):16142-16162
%X Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.Analyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations with treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model. A multi-state model was used for further insight into the relation between CHEK2 c.1100delC status, treatment, CBC risk and death.There was no evidence for differential associations of therapy with CBC risk by CHEK2 c.1100delC status. The strongest association with reduced CBC risk was observed for the combination of chemotherapy and endocrine therapy [HR (95
%K CHEK2 c.1100delC germline genetic variant (Other)
%K contralateral breast cancer risk (Other)
%K radiotherapy (Other)
%K survival (Other)
%K systemic treatment (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37401034
%R 10.1002/cam4.6272
%U https://inrepo02.dkfz.de/record/277325