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@ARTICLE{Morra:277325,
      author       = {A. Morra and M. A. C. Schreurs and I. L. Andrulis and H.
                      Anton-Culver and A. Augustinsson and M. W. Beckmann and S.
                      Behrens$^*$ and S. E. Bojesen and M. K. Bolla and H.
                      Brauch$^*$ and A. Broeks and S. S. Buys and N. J. Camp and
                      J. E. Castelao and M. H. Cessna and J. Chang-Claude$^*$ and
                      W. K. Chung and S. V. Colonna and F. J. Couch and A. Cox and
                      S. S. Cross and K. Czene and M. B. Daly and J. Dennis and P.
                      Devilee and T. Dörk and A. M. Dunning and M. Dwek and D. F.
                      Easton and D. M. Eccles and M. Eriksson and D. G. Evans and
                      P. A. Fasching and T. N. Fehm and J. D. Figueroa and H.
                      Flyger and M. Gabrielson and M. Gago-Dominguez and M.
                      García-Closas and J. A. García-Sáenz and J. Genkinger and
                      F. Grassmann and M. Gündert$^*$ and E. Hahnen and C. A.
                      Haiman and U. Hamann$^*$ and P. A. Harrington and J. M.
                      Hartikainen and R. Hoppe and J. L. Hopper and R. S. Houlston
                      and A. Howell and A. Jakubowska and W. Janni and H.
                      Jernström and E. M. John and N. Johnson and M. E. Jones and
                      V. N. Kristensen and A. W. Kurian and D. Lambrechts and L.
                      Le Marchand and A. Lindblom and J. Lubiński and M. P. Lux
                      and A. Mannermaa and D. Mavroudis and A. M. Mulligan and T.
                      A. Muranen and H. Nevanlinna and I. Nevelsteen and P. Neven
                      and W. G. Newman and N. Obi and K. Offit and A. F. Olshan
                      and T.-W. Park-Simon and A. V. Patel and P. Peterlongo and
                      K.-A. Phillips and D. Plaseska-Karanfilska and E. C. Polley
                      and N. Presneau and K. Pylkäs and B. Rack and P. Radice and
                      M. U. Rashid and V. Rhenius and M. Robson and A. Romero and
                      E. Saloustros and E. J. Sawyer and R. K. Schmutzler and S.
                      Schuetze and C. Scott and M. Shah and S. Smichkoska and M.
                      C. Southey and W. J. Tapper and L. R. Teras and R. A. E. M.
                      Tollenaar and K. Tomczyk and I. Tomlinson and M. A. Troester
                      and C. M. Vachon and E. M. van Veen and Q. Wang and C. Wendt
                      and H. Wildiers and R. Winqvist and A. Ziogas and P. Hall
                      and P. D. P. Pharoah and M. A. Adank and A. Hollestelle and
                      M. K. Schmidt and M. J. Hooning},
      collaboration = {NBCS Collaborators and A. Investigators and k.
                      Investigators},
      othercontributors = {K. K. Sahlberg and A.-L. Børresen-Dale and I. T. Gram and
                          K. S. Olsen and O. Engebråten and B. Naume and J. Geisler
                          and G. I. Grenaker Alnaes and C. Clarke and D. Marsh and R.
                          Scott and R. Baxter and D. Yip and J. Carpenter and A. Davis
                          and N. Pathmanathan and P. Simpson and J. D. Graham and M.
                          Sachchithananthan and D. Amor and L. Andrews and Y. Antill
                          and R. Balleine and J. Beesley and I. Bennett and M. Bogwitz
                          and L. Botes and M. Brennan and M. Brown and M. Buckley and
                          J. Burke and P. Butow and L. Caldon and I. Campbell and M.
                          Cao and A. Chakrabarti and D. Chauhan and M. Chauhan and G.
                          Chenevix-Trench and A. Christian and P. Cohen and A. Colley
                          and A. Crook and J. Cui and E. Courtney and M. Cummings and
                          S.-J. Dawson and A. DeFazio and M. Delatycki and R. Dickson
                          and J. Dixon and T. Edkins and S. Edwards and G. Farshid and
                          A. Fellows and G. Fenton and M. Field and J. Flanagan and P.
                          Fong and L. Forrest and S. Fox and J. French and M.
                          Friedlander and C. Gaff and M. Gattas and P. George and S.
                          Greening and M. Harris and S. Hart and N. Hayward and J.
                          Hopper and C. Hoskins and C. Hunt and P. James and M.
                          Jenkins and A. Kidd and J. Kirk and J. Koehler and J.
                          Kollias and S. Lakhani and M. Lawrence and J. Lee and S. Li
                          and G. Lindeman and L. Lipton and L. Lobb and S. Loi and G.
                          Mann and D. Marsh and S. A. McLachlan and B. Meiser and R.
                          Milne and S. Nightingale and S. O'Connell and S. O'Sullivan
                          and D. G. Ortega and N. Pachter and J.-M. Pang and G. Pathak
                          and B. Patterson and A. Pearn and K. Phillips and E. Pieper
                          and S. Ramus and E. Rickard and B. Robinson and M. Saleh and
                          A. Skandarajah and E. Salisbury and C. Saunders and J.
                          Saunus and R. Scott and C. Scott and A. Sexton and A.
                          Shelling and P. Simpson and M. Southey and A. Spurdle and J.
                          Taylor and R. Taylor and H. Thorne and A. Trainer and K.
                          Tucker and J. Visvader and L. Walker and R. Williams and I.
                          Winship and M. A. Young and M. Zaheed},
      title        = {{A}ssociation of the {CHEK}2 c.1100del{C} variant,
                      radiotherapy, and systemic treatment with contralateral
                      breast cancer risk and breast cancer-specific survival.},
      journal      = {Cancer medicine},
      volume       = {12},
      number       = {15},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-01343},
      pages        = {16142-16162},
      year         = {2023},
      note         = {2023 Aug;12(15):16142-16162},
      abstract     = {Breast cancer (BC) patients with a germline CHEK2
                      c.1100delC variant have an increased risk of contralateral
                      BC (CBC) and worse BC-specific survival (BCSS) compared to
                      non-carriers.To assessed the associations of CHEK2
                      c.1100delC, radiotherapy, and systemic treatment with CBC
                      risk and BCSS.Analyses were based on 82,701 women diagnosed
                      with a first primary invasive BC including 963 CHEK2
                      c.1100delC carriers; median follow-up was 9.1 years.
                      Differential associations with treatment by CHEK2 c.1100delC
                      status were tested by including interaction terms in a
                      multivariable Cox regression model. A multi-state model was
                      used for further insight into the relation between CHEK2
                      c.1100delC status, treatment, CBC risk and death.There was
                      no evidence for differential associations of therapy with
                      CBC risk by CHEK2 c.1100delC status. The strongest
                      association with reduced CBC risk was observed for the
                      combination of chemotherapy and endocrine therapy [HR
                      $(95\%$ CI): 0.66 (0.55-0.78)]. No association was observed
                      with radiotherapy. Results from the multi-state model showed
                      shorter BCSS for CHEK2 c.1100delC carriers versus
                      non-carriers also after accounting for CBC occurrence [HR
                      $(95\%$ CI): 1.30 (1.09-1.56)].Systemic therapy was
                      associated with reduced CBC risk irrespective of CHEK2
                      c.1100delC status. Moreover, CHEK2 c.1100delC carriers had
                      shorter BCSS, which appears not to be fully explained by
                      their CBC risk.},
      keywords     = {CHEK2 c.1100delC germline genetic variant (Other) /
                      contralateral breast cancer risk (Other) / radiotherapy
                      (Other) / survival (Other) / systemic treatment (Other)},
      cin          = {C020 / B072 / B070 / TU01 / C080},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)B072-20160331 /
                      I:(DE-He78)B070-20160331 / I:(DE-He78)TU01-20160331 /
                      I:(DE-He78)C080-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37401034},
      doi          = {10.1002/cam4.6272},
      url          = {https://inrepo02.dkfz.de/record/277325},
}