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@ARTICLE{Fuchs:277340,
      author       = {S. Fuchs$^*$ and C. Danßmann and F. Klironomos and A.
                      Winkler and J. Fallmann and L.-M. Kruetzfeldt and A.
                      Szymansky and J. Naderi and S. H. Bernhart and L.
                      Grunewald$^*$ and K. Helmsauer and E. Rodriguez-Fos and M.
                      Kirchner and P. Mertins and K. Astrahantseff and C. Suenkel
                      and J. Toedling$^*$ and F. Meggetto and M. Remke$^*$ and P.
                      F. Stadler and P. Hundsdoerfer and H. E. Deubzer$^*$ and A.
                      Künkele$^*$ and P. Lang and J. Fuchs and A. G. Henssen$^*$
                      and A. Eggert$^*$ and N. Rajewsky and F. Hertwig$^*$ and J.
                      Schulte$^*$},
      title        = {{D}efining the landscape of circular {RNA}s in
                      neuroblastoma unveils a global suppressive function of
                      {MYCN}.},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2023-01348},
      pages        = {3936},
      year         = {2023},
      abstract     = {Circular RNAs (circRNAs) are a regulatory RNA class. While
                      cancer-driving functions have been identified for single
                      circRNAs, how they modulate gene expression in cancer is not
                      well understood. We investigate circRNA expression in the
                      pediatric malignancy, neuroblastoma, through deep
                      whole-transcriptome sequencing in 104 primary neuroblastomas
                      covering all risk groups. We demonstrate that MYCN
                      amplification, which defines a subset of high-risk cases,
                      causes globally suppressed circRNA biogenesis directly
                      dependent on the DHX9 RNA helicase. We detect similar
                      mechanisms in shaping circRNA expression in the pediatric
                      cancer medulloblastoma implying a general MYCN effect.
                      Comparisons to other cancers identify 25 circRNAs that are
                      specifically upregulated in neuroblastoma, including
                      circARID1A. Transcribed from the ARID1A tumor suppressor
                      gene, circARID1A promotes cell growth and survival, mediated
                      by direct interaction with the KHSRP RNA-binding protein.
                      Our study highlights the importance of MYCN regulating
                      circRNAs in cancer and identifies molecular mechanisms,
                      which explain their contribution to neuroblastoma
                      pathogenesis.},
      cin          = {BE01 / ED01},
      ddc          = {500},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37402719},
      doi          = {10.1038/s41467-023-38747-4},
      url          = {https://inrepo02.dkfz.de/record/277340},
}