%0 Journal Article
%A Rosas, Juan C
%A Aguado-Barrera, Miguel E
%A Azria, David
%A Briers, Erik
%A Elliott, Rebecca
%A Farcy-Jacquet, Marie-Pierre
%A Giraldo, Alexandra
%A Gutiérrez-Enríquez, Sara
%A Rancati, Tiziana
%A Rattay, Tim
%A Reyes, Victoria
%A Rosenstein, Barry
%A De Ruysscher, Dirk
%A Sperk, Elena
%A Stobart, Hilary
%A Talbot, Christopher
%A Vega, Ana
%A Taboada-Valladares, Begoña
%A Veldeman, Liv
%A Ward, Tim
%A Webb, Adam
%A West, Catharine
%A Chang-Claude, Jenny
%A Seibold, Petra
%T (Pre)treatment risk factors for late fatigue and fatigue trajectories following radiotherapy for breast cancer.
%J International journal of cancer
%V 153
%N 9
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2023-01350
%P 1579-1591
%D 2023
%Z #EA:C020# / 2023 Nov 1;153(9):1579-1591
%X Fatigue is common in breast-cancer survivors. Our study assessed fatigue longitudinally in breast cancer patients receiving adjuvant radiotherapy (RT) and aimed to identify risk factors associated with long-term fatigue and underlying fatigue trajectories. Fatigue was measured in a prospective multicenter cohort (REQUITE) using the Multidimensional Fatigue Inventory (MFI-20) and analyzed using mixed models. Multivariable logistic models identified factors associated with fatigue dimensions at 2 years post-RT and latent class growth analysis identified individual fatigue trajectories. A total of 1443, 1302, 1203 and 1098 patients completed the MFI-20 at baseline, end of RT, after 1 and 2 years. Overall, levels of fatigue significantly increased from baseline to end of RT for all fatigue dimensions (P < .05) and returned to baseline levels after 2 years. A quarter of patients were assigned to latent trajectory high (23.7
%K breast cancer (Other)
%K determinants (Other)
%K fatigue (Other)
%K longitudinal trajectories (Other)
%K radiotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37403702
%R 10.1002/ijc.34640
%U https://inrepo02.dkfz.de/record/277342