TY  - JOUR
AU  - Rosas, Juan C
AU  - Aguado-Barrera, Miguel E
AU  - Azria, David
AU  - Briers, Erik
AU  - Elliott, Rebecca
AU  - Farcy-Jacquet, Marie-Pierre
AU  - Giraldo, Alexandra
AU  - Gutiérrez-Enríquez, Sara
AU  - Rancati, Tiziana
AU  - Rattay, Tim
AU  - Reyes, Victoria
AU  - Rosenstein, Barry
AU  - De Ruysscher, Dirk
AU  - Sperk, Elena
AU  - Stobart, Hilary
AU  - Talbot, Christopher
AU  - Vega, Ana
AU  - Taboada-Valladares, Begoña
AU  - Veldeman, Liv
AU  - Ward, Tim
AU  - Webb, Adam
AU  - West, Catharine
AU  - Chang-Claude, Jenny
AU  - Seibold, Petra
TI  - (Pre)treatment risk factors for late fatigue and fatigue trajectories following radiotherapy for breast cancer.
JO  - International journal of cancer
VL  - 153
IS  - 9
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2023-01350
SP  - 1579-1591
PY  - 2023
N1  - #EA:C020# / 2023 Nov 1;153(9):1579-1591
AB  - Fatigue is common in breast-cancer survivors. Our study assessed fatigue longitudinally in breast cancer patients receiving adjuvant radiotherapy (RT) and aimed to identify risk factors associated with long-term fatigue and underlying fatigue trajectories. Fatigue was measured in a prospective multicenter cohort (REQUITE) using the Multidimensional Fatigue Inventory (MFI-20) and analyzed using mixed models. Multivariable logistic models identified factors associated with fatigue dimensions at 2 years post-RT and latent class growth analysis identified individual fatigue trajectories. A total of 1443, 1302, 1203 and 1098 patients completed the MFI-20 at baseline, end of RT, after 1 and 2 years. Overall, levels of fatigue significantly increased from baseline to end of RT for all fatigue dimensions (P < .05) and returned to baseline levels after 2 years. A quarter of patients were assigned to latent trajectory high (23.7
KW  - breast cancer (Other)
KW  - determinants (Other)
KW  - fatigue (Other)
KW  - longitudinal trajectories (Other)
KW  - radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37403702
DO  - DOI:10.1002/ijc.34640
UR  - https://inrepo02.dkfz.de/record/277342
ER  -