% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Rosas:277342,
      author       = {J. C. Rosas$^*$ and M. E. Aguado-Barrera and D. Azria and
                      E. Briers and R. Elliott and M.-P. Farcy-Jacquet and A.
                      Giraldo and S. Gutiérrez-Enríquez and T. Rancati and T.
                      Rattay and V. Reyes and B. Rosenstein and D. De Ruysscher
                      and E. Sperk and H. Stobart and C. Talbot and A. Vega and B.
                      Taboada-Valladares and L. Veldeman and T. Ward and A. Webb
                      and C. West and J. Chang-Claude$^*$ and P. Seibold$^*$},
      collaboration = {R. Consortium},
      title        = {({P}re)treatment risk factors for late fatigue and fatigue
                      trajectories following radiotherapy for breast cancer.},
      journal      = {International journal of cancer},
      volume       = {153},
      number       = {9},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-01350},
      pages        = {1579-1591},
      year         = {2023},
      note         = {#EA:C020# / 2023 Nov 1;153(9):1579-1591},
      abstract     = {Fatigue is common in breast-cancer survivors. Our study
                      assessed fatigue longitudinally in breast cancer patients
                      receiving adjuvant radiotherapy (RT) and aimed to identify
                      risk factors associated with long-term fatigue and
                      underlying fatigue trajectories. Fatigue was measured in a
                      prospective multicenter cohort (REQUITE) using the
                      Multidimensional Fatigue Inventory (MFI-20) and analyzed
                      using mixed models. Multivariable logistic models identified
                      factors associated with fatigue dimensions at 2 years
                      post-RT and latent class growth analysis identified
                      individual fatigue trajectories. A total of 1443, 1302, 1203
                      and 1098 patients completed the MFI-20 at baseline, end of
                      RT, after 1 and 2 years. Overall, levels of fatigue
                      significantly increased from baseline to end of RT for all
                      fatigue dimensions (P < .05) and returned to baseline levels
                      after 2 years. A quarter of patients were assigned to latent
                      trajectory high $(23.7\%)$ and moderate $(24.8\%)$ fatigue
                      classes, while $46.3\%$ and $5.2\%$ to the low and
                      decreasing fatigue classes, respectively. Factors associated
                      with multiple fatigue dimensions at 2 years include age,
                      BMI, global health status, insomnia, pain, dyspnea and
                      depression. Fatigue present at baseline was consistently
                      associated with all five MFI-20 fatigue dimensions
                      (ORGeneralFatigue = 3.81, P < .001). From latent trajectory
                      analysis, patients with a combination of factors such as
                      pain, insomnia, depression, younger age and endocrine
                      therapy had a particularly high risk of developing early and
                      persistent high fatigue years after treatment. Our results
                      confirmed the multidimensional nature of fatigue and will
                      help clinicians identify breast cancer patients at higher
                      risk of having persistent/late fatigue so that tailored
                      interventions can be delivered.},
      keywords     = {breast cancer (Other) / determinants (Other) / fatigue
                      (Other) / longitudinal trajectories (Other) / radiotherapy
                      (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37403702},
      doi          = {10.1002/ijc.34640},
      url          = {https://inrepo02.dkfz.de/record/277342},
}