TY  - JOUR
AU  - Hickey, Samantha
AU  - Reichert, Andreas
AU  - Ptacek, Wolfgang
AU  - Bielak, Lars
AU  - Reiss, Simon
AU  - Fischer, Johannes
AU  - Gunashekar, Deepa Darshini
AU  - Bortfeld, Thomas
AU  - Bock, Michael
TI  - Simultaneous T2 -weighted real-time MRI of two orthogonal slices.
JO  - Magnetic resonance in medicine
VL  - 90
IS  - 6
SN  - 1522-2594
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2023-01380
SP  - 2388-2399
PY  - 2023
N1  - 2023 Dec;90(6):2388-2399
AB  - MR guidance is used during therapy to detect and compensate for lesion motion. T2 -weighted MRI often has a superior lesion contrast in comparison to T1 -weighted real-time imaging. The purpose of this work was to design a fast T2 -weighted sequence capable of simultaneously acquiring two orthogonal slices, enabling real-time tracking of lesions.To generate a T2 contrast in two orthogonal slices simultaneously, a sequence (Ortho-SFFP-Echo) was designed that samples the T2 -weighted spin echo (S- ) signal in a TR-interleaved acquisition of two slices. Slice selection and phase-encoding directions are swapped between the slices, leading to a unique set of spin-echo signal conditions. To minimize motion-related signal dephasing, additional flow-compensation strategies are implemented. In both the abdominal breathing phantom and in vivo experiments, a time series was acquired using Ortho-SSFP-Echo. The centroid of the target was tracked in postprocessing steps.In the phantom, the lesion could be identified and delineated in the dynamic images. In the volunteer experiments, the kidney was visualized with a T2 contrast at a temporal resolution of 0.45 s under free-breathing conditions. A respiratory belt demonstrated a strong correlation with the time course of the kidney centroid in the head-foot direction. A hypointense saturation band at the slice overlap did not inhibit lesion tracking in the semi-automatic postprocessing steps.The Ortho-SFFP-Echo sequence delivers real-time images with a T2 -weighted contrast in two orthogonal slices. The sequence allows for simultaneous acquisition, which could be beneficial for real-time motion tracking in radiotherapy or interventional MRI.
KW  - MR-guidance (Other)
KW  - MR-guided radiation therapy (Other)
KW  - magnetic resonance imaging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37427459
DO  - DOI:10.1002/mrm.29795
UR  - https://inrepo02.dkfz.de/record/277443
ER  -