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@ARTICLE{Hickey:277443,
      author       = {S. Hickey and A. Reichert and W. Ptacek and L. Bielak$^*$
                      and S. Reiss and J. Fischer and D. D. Gunashekar and T.
                      Bortfeld and M. Bock},
      title        = {{S}imultaneous {T}2 -weighted real-time {MRI} of two
                      orthogonal slices.},
      journal      = {Magnetic resonance in medicine},
      volume       = {90},
      number       = {6},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-01380},
      pages        = {2388-2399},
      year         = {2023},
      note         = {2023 Dec;90(6):2388-2399},
      abstract     = {MR guidance is used during therapy to detect and compensate
                      for lesion motion. T2 -weighted MRI often has a superior
                      lesion contrast in comparison to T1 -weighted real-time
                      imaging. The purpose of this work was to design a fast T2
                      -weighted sequence capable of simultaneously acquiring two
                      orthogonal slices, enabling real-time tracking of lesions.To
                      generate a T2 contrast in two orthogonal slices
                      simultaneously, a sequence (Ortho-SFFP-Echo) was designed
                      that samples the T2 -weighted spin echo (S- ) signal in a
                      TR-interleaved acquisition of two slices. Slice selection
                      and phase-encoding directions are swapped between the
                      slices, leading to a unique set of spin-echo signal
                      conditions. To minimize motion-related signal dephasing,
                      additional flow-compensation strategies are implemented. In
                      both the abdominal breathing phantom and in vivo
                      experiments, a time series was acquired using
                      Ortho-SSFP-Echo. The centroid of the target was tracked in
                      postprocessing steps.In the phantom, the lesion could be
                      identified and delineated in the dynamic images. In the
                      volunteer experiments, the kidney was visualized with a T2
                      contrast at a temporal resolution of 0.45 s under
                      free-breathing conditions. A respiratory belt demonstrated a
                      strong correlation with the time course of the kidney
                      centroid in the head-foot direction. A hypointense
                      saturation band at the slice overlap did not inhibit lesion
                      tracking in the semi-automatic postprocessing steps.The
                      Ortho-SFFP-Echo sequence delivers real-time images with a T2
                      -weighted contrast in two orthogonal slices. The sequence
                      allows for simultaneous acquisition, which could be
                      beneficial for real-time motion tracking in radiotherapy or
                      interventional MRI.},
      keywords     = {MR-guidance (Other) / MR-guided radiation therapy (Other) /
                      magnetic resonance imaging (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37427459},
      doi          = {10.1002/mrm.29795},
      url          = {https://inrepo02.dkfz.de/record/277443},
}