% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mansell:277462,
      author       = {E. Mansell and D. S. Lin$^*$ and S. J. Loughran and M.
                      Milsom$^*$ and J. J. Trowbridge},
      title        = {{N}ew {I}nsight into the {C}auses, {C}onsequences and
                      {C}orrection of {H}ematopoietic {S}tem {C}ell {A}geing.},
      journal      = {Experimental hematology},
      volume       = {125–126},
      number       = {September–October 2023},
      issn         = {0531-5573},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01389},
      pages        = {1-5},
      year         = {2023},
      note         = {#EA:A010#LA:A012# / Volumes 125–126, September–October
                      2023, Pages 1-5 / Perspective},
      abstract     = {Ageing of hematopoietic stem cells (HSCs) is characterised
                      by lineage bias, increased clonal expansion and functional
                      decrease. At the molecular level, aged HSCs typically
                      display metabolic dysregulation, upregulation of
                      inflammatory pathways and downregulation of DNA repair
                      pathways. Cellular ageing of HSCs, driven by cell-intrinsic
                      and cell-extrinsic factors, causes predisposition to
                      anaemia, adaptive immune compromise, myelodysplasia and
                      malignancy. In fact, most hematological diseases are
                      strongly associated with age. But what is the biological
                      foundation for decreased fitness with age? And are there
                      therapeutic windows to resolve age-related hematopoietic
                      decline? These questions were the focus of the International
                      Society for Experimental Hematology New Investigator
                      Committee Fall 2022 Webinar. This review touches on the
                      latest insights from two leading laboratories into
                      inflammatory- and niche- driven stem cell ageing and
                      includes speculation on strategies to prevent or correct
                      age-related decline in HSC function (see Fig 1).},
      subtyp        = {Review Article},
      cin          = {A010 / A012},
      ddc          = {610},
      cid          = {I:(DE-He78)A010-20160331 / I:(DE-He78)A012-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37433369},
      doi          = {10.1016/j.exphem.2023.07.002},
      url          = {https://inrepo02.dkfz.de/record/277462},
}