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| 001 | 277462 | ||
| 005 | 20240229155017.0 | ||
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| 100 | 1 | _ | |a Mansell, Els |b 0 |
| 245 | _ | _ | |a New Insight into the Causes, Consequences and Correction of Hematopoietic Stem Cell Ageing. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2023 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a #EA:A010#LA:A012# / Volumes 125–126, September–October 2023, Pages 1-5 / Perspective |
| 520 | _ | _ | |a Ageing of hematopoietic stem cells (HSCs) is characterised by lineage bias, increased clonal expansion and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways and downregulation of DNA repair pathways. Cellular ageing of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes predisposition to anaemia, adaptive immune compromise, myelodysplasia and malignancy. In fact, most hematological diseases are strongly associated with age. But what is the biological foundation for decreased fitness with age? And are there therapeutic windows to resolve age-related hematopoietic decline? These questions were the focus of the International Society for Experimental Hematology New Investigator Committee Fall 2022 Webinar. This review touches on the latest insights from two leading laboratories into inflammatory- and niche- driven stem cell ageing and includes speculation on strategies to prevent or correct age-related decline in HSC function (see Fig 1). |
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| 700 | 1 | _ | |a Lin, Dawn S |0 P:(DE-HGF)0 |b 1 |e First author |
| 700 | 1 | _ | |a Loughran, Stephen J |b 2 |
| 700 | 1 | _ | |a Milsom, Michael |0 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |b 3 |e Last author |u dkfz |
| 700 | 1 | _ | |a Trowbridge, Jennifer J |b 4 |
| 773 | _ | _ | |a 10.1016/j.exphem.2023.07.002 |g p. S0301472X23016144 |0 PERI:(DE-600)2005403-8 |n September–October 2023 |p 1-5 |t Experimental hematology |v 125–126 |y 2023 |x 0531-5573 |
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