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@ARTICLE{Eichhorn:277702,
      author       = {F. Eichhorn and A. Weigert$^*$ and R. Nandigama and L. V.
                      Klotz and J. Wilhelm and M. Kriegsmann and M. Allgäuer and
                      T. Muley and P. Christopoulos and R. Savai$^*$ and M. E.
                      Eichhorn and H. Winter},
      title        = {{P}rognostic {I}mpact of the {I}mmune-{C}ell {I}nfiltrate
                      in {N}1-{P}ositive {N}on-{S}mall-{C}ell {L}ung {C}ancer.},
      journal      = {Clinical lung cancer},
      volume       = {24},
      number       = {8},
      issn         = {1525-7304},
      address      = {Dallas, Tex.},
      publisher    = {Cancer Information Group},
      reportid     = {DKFZ-2023-01419},
      pages        = {:706-716.e1},
      year         = {2023},
      note         = {2023 Dec;24(8):706-716.e1},
      abstract     = {The tumoral immune milieu plays a crucial role for the
                      development of non-small-cell lung cancer (NSCLC) and may
                      influence individual prognosis. We analyzed the predictive
                      role of immune cell infiltrates after curative lung cancer
                      surgery.The tumoral immune-cell infiltrate from 174 patients
                      with pN1 NSCLC and adjuvant chemotherapy was characterized
                      using immunofluorescence staining. The density and
                      distribution of specific immune cells in tumor center (TU),
                      invasive front (IF) and normal tissue (NORM) were correlated
                      with clinical parameters and survival data.Tumor specific
                      survival (TSS) of all patients was $69.9\%$ at 5 years. The
                      density of tumor infiltrating lymphocytes (TIL) was higher
                      in TU and IF than in NORM. High TIL density in TU (low vs.
                      high: $62.0\%$ vs. $86.7\%;$ p = .011) and the presence of
                      cytotoxic T-Lymphocytes (CTLs) in TU and IF were associated
                      with improved TSS (positive vs. negative: $90.6\%$ vs.
                      $64.7\%$ p = .024). High TIL-density correlated with
                      programmed death-ligand 1 expression levels $≥50\%$ (p <
                      .001). Multivariate analysis identified accumulation of TIL
                      (p = .016) and low Treg density (p = .003) in TU as negative
                      prognostic predictors in squamous cell carcinoma (p = .025),
                      whereas M1-like tumor- associated macrophages (p = .019) and
                      high programmed death-ligand 1 status (p = .038) were
                      associated with better survival in adenocarcinoma.The
                      assessment of specific intratumoral immune cells may serve
                      as a prognostic predictor in pN1 NSCLC. However differences
                      were observed related to adenocarcinoma or squamous cell
                      carcinoma histology. Prospective assessment of the
                      immune-cell infiltrate and further clarification of its
                      prognostic relevance could assist patient selection for
                      upcoming perioperative immunotherapies.},
      keywords     = {PD-L1-expression (Other) / Peritumoral immune milieu
                      (Other) / Pulmonary carcinoma (Other) / Stage II/III lung
                      cancer (Other) / Surgery (Other) / Tumor infiltrating
                      lymphocytes (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37460340},
      doi          = {10.1016/j.cllc.2023.06.013},
      url          = {https://inrepo02.dkfz.de/record/277702},
}