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@ARTICLE{Haake:277711,
      author       = {M. Haake and B. Haack and T. Schäfer and P. Harter$^*$ and
                      G. Mattavelli and P. Eiring and N. Vashist and F. Wedekink
                      and S. Genssler and B. Fischer and J. Dahlhoff and F.
                      Mokhtari and A. Kuzkina and M. J. P. Welters and T. M. Benz
                      and L. Sorger and V. Thiemann and G. Almanzar and M. Selle
                      and K. Thein and J. Späth and M. C. Gonzalez and C.
                      Reitinger and A. Ipsen-Escobedo and K. Wistuba-Hamprecht and
                      K. Eichler and K. Filipski$^*$ and P. S. Zeiner$^*$ and R.
                      Beschorner and R. Goedemans and F. H. Gogolla and H. Hackl
                      and R. W. Rooswinkel and A. Thiem and P. R. Roche and H.
                      Joshi and D. Pühringer and A. Wöckel and J. E. Diessner
                      and M. Rüdiger and E. Leo and P. F. Cheng and M. P.
                      Levesque and M. Goebeler and M. Sauer and F. Nimmerjahn and
                      C. Schuberth-Wagner and S. von Felten and M. Mittelbronn and
                      M. Mehling and A. Beilhack and S. H. van der Burg and A.
                      Riedel and B. Weide and R. Dummer and J. Wischhusen},
      title        = {{T}umor-derived {GDF}-15 blocks {LFA}-1 dependent {T} cell
                      recruitment and suppresses responses to anti-{PD}-1
                      treatment.},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2023-01428},
      pages        = {4253},
      year         = {2023},
      abstract     = {Immune checkpoint blockade therapy is beneficial and even
                      curative for some cancer patients. However, the majority
                      don't respond to immune therapy. Across different tumor
                      types, pre-existing T cell infiltrates predict response to
                      checkpoint-based immunotherapy. Based on in vitro
                      pharmacological studies, mouse models and analyses of human
                      melanoma patients, we show that the cytokine GDF-15 impairs
                      LFA-1/β2-integrin-mediated adhesion of T cells to activated
                      endothelial cells, which is a pre-requisite of T cell
                      extravasation. In melanoma patients, GDF-15 serum levels
                      strongly correlate with failure of PD-1-based immune
                      checkpoint blockade therapy. Neutralization of GDF-15
                      improves both T cell trafficking and therapy efficiency in
                      murine tumor models. Thus GDF-15, beside its known role in
                      cancer-related anorexia and cachexia, emerges as a regulator
                      of T cell extravasation into the tumor microenvironment,
                      which provides an even stronger rationale for therapeutic
                      anti-GDF-15 antibody development.},
      keywords     = {Humans / Mice / Animals / T-Lymphocytes: pathology /
                      Lymphocyte Function-Associated Antigen-1 / Endothelial
                      Cells: pathology / Immune Checkpoint Inhibitors:
                      pharmacology / Immune Checkpoint Inhibitors: therapeutic use
                      / Melanoma: pathology / Immunotherapy / Tumor
                      Microenvironment / Lymphocyte Function-Associated Antigen-1
                      (NLM Chemicals) / Immune Checkpoint Inhibitors (NLM
                      Chemicals)},
      cin          = {FM01},
      ddc          = {500},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37474523},
      pmc          = {pmc:PMC10359308},
      doi          = {10.1038/s41467-023-39817-3},
      url          = {https://inrepo02.dkfz.de/record/277711},
}