%0 Journal Article
%A Weissinger, Matthias
%A Seyfried, Kyra Celine
%A Ursprung, Stephan
%A Castaneda-Vega, Salvador
%A Seith, Ferdinand
%A von Beschwitz, Sebastian
%A Vogel, Jonas
%A Ghibes, Patrick
%A Nikolaou, Konstantin
%A la Fougère, Christian
%A Dittmann, Helmut
%T Non-invasive estimation of split renal function from routine 68Ga-SSR-PET/CT scans.
%J Frontiers in medicine
%V 10
%@ 2296-858X
%C Lausanne
%I Frontiers Media
%M DKFZ-2023-01443
%P 1169451
%D 2023
%X Patients with impaired kidney function are at elevated risk for nephrotoxicity and hematotoxicity from peptide receptor radionuclide therapy (PPRT) for advanced neuroendocrine tumors. Somatostatin receptor (SSR)-PET/CT imaging is the method of choice to identify sufficient SSR expression as a prerequisite for PRRT. Therefore, our study aimed to explore whether split renal function could be evaluated using imaging data from routine SSR-PET/CT prior to PRRT.In total, 25 consecutive patients who underwent SSR-PET/CT (Siemens Biograph mCT®) before PRRT between June 2019 and December 2020 were enrolled in this retrospective study. PET acquisition in the caudocranial direction started at 20 ± 0.5 min after an i.v. injection of 173 ± 20 MBq [68Ga]Ga-ha DOTATATE, and the kidneys were scanned at 32 ± 0.5 min p.i. The renal parenchyma was segmented semi-automatically using an SUV-based isocontour (SUV between 5 and 15). Multiple parameters including SUVmean of renal parenchyma and blood pool, as well as parenchyma volume, were extracted, and accumulation index (ACI: renal parenchyma volume/SUVmean) and total kidney accumulation (TKA: SUVmean x renal parenchyma volume) were calculated. All data were correlated with the reference standard tubular extraction rate (TER-MAG) from [99mTc]Tc-MAG3 scintigraphy and glomerular filtration rate (GFRCDK - EPI).SUVmean of the parenchymal tracer retention showed a negative correlation with TERMAG (r: -0.519, p < 0.001) and GFRCDK - EPI (r: -0.555, p < 0.001) at 32 min p.i. The herein-introduced ACI revealed a significant correlation (p < 0.05) with the total tubular function (r: 0.482), glomerular renal function (r: 0.461), split renal function (r: 0.916), and absolute single-sided renal function (r: 0.549). The mean difference between the split renal function determined by renal scintigraphy and ACI was 1.8 ± 4.2 
%K DOTATATE (Other)
%K NET (neuro-endocrinal tumors) (Other)
%K PRRT (peptide receptor radionuclide therapy) (Other)
%K SSR PET/CT (Other)
%K accumulation index (Other)
%K single-sided renal function (Other)
%K split renal function (Other)
%K total kidney accumulation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37448797
%2 pmc:PMC10337782
%R 10.3389/fmed.2023.1169451
%U https://inrepo02.dkfz.de/record/277726