TY  - JOUR
AU  - Weissinger, Matthias
AU  - Seyfried, Kyra Celine
AU  - Ursprung, Stephan
AU  - Castaneda-Vega, Salvador
AU  - Seith, Ferdinand
AU  - von Beschwitz, Sebastian
AU  - Vogel, Jonas
AU  - Ghibes, Patrick
AU  - Nikolaou, Konstantin
AU  - la Fougère, Christian
AU  - Dittmann, Helmut
TI  - Non-invasive estimation of split renal function from routine 68Ga-SSR-PET/CT scans.
JO  - Frontiers in medicine
VL  - 10
SN  - 2296-858X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2023-01443
SP  - 1169451
PY  - 2023
AB  - Patients with impaired kidney function are at elevated risk for nephrotoxicity and hematotoxicity from peptide receptor radionuclide therapy (PPRT) for advanced neuroendocrine tumors. Somatostatin receptor (SSR)-PET/CT imaging is the method of choice to identify sufficient SSR expression as a prerequisite for PRRT. Therefore, our study aimed to explore whether split renal function could be evaluated using imaging data from routine SSR-PET/CT prior to PRRT.In total, 25 consecutive patients who underwent SSR-PET/CT (Siemens Biograph mCT®) before PRRT between June 2019 and December 2020 were enrolled in this retrospective study. PET acquisition in the caudocranial direction started at 20 ± 0.5 min after an i.v. injection of 173 ± 20 MBq [68Ga]Ga-ha DOTATATE, and the kidneys were scanned at 32 ± 0.5 min p.i. The renal parenchyma was segmented semi-automatically using an SUV-based isocontour (SUV between 5 and 15). Multiple parameters including SUVmean of renal parenchyma and blood pool, as well as parenchyma volume, were extracted, and accumulation index (ACI: renal parenchyma volume/SUVmean) and total kidney accumulation (TKA: SUVmean x renal parenchyma volume) were calculated. All data were correlated with the reference standard tubular extraction rate (TER-MAG) from [99mTc]Tc-MAG3 scintigraphy and glomerular filtration rate (GFRCDK - EPI).SUVmean of the parenchymal tracer retention showed a negative correlation with TERMAG (r: -0.519, p < 0.001) and GFRCDK - EPI (r: -0.555, p < 0.001) at 32 min p.i. The herein-introduced ACI revealed a significant correlation (p < 0.05) with the total tubular function (r: 0.482), glomerular renal function (r: 0.461), split renal function (r: 0.916), and absolute single-sided renal function (r: 0.549). The mean difference between the split renal function determined by renal scintigraphy and ACI was 1.8 ± 4.2 
KW  - DOTATATE (Other)
KW  - NET (neuro-endocrinal tumors) (Other)
KW  - PRRT (peptide receptor radionuclide therapy) (Other)
KW  - SSR PET/CT (Other)
KW  - accumulation index (Other)
KW  - single-sided renal function (Other)
KW  - split renal function (Other)
KW  - total kidney accumulation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37448797
C2  - pmc:PMC10337782
DO  - DOI:10.3389/fmed.2023.1169451
UR  - https://inrepo02.dkfz.de/record/277726
ER  -