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@ARTICLE{Weissinger:277726,
      author       = {M. Weissinger and K. C. Seyfried and S. Ursprung and S.
                      Castaneda-Vega and F. Seith and S. von Beschwitz and J.
                      Vogel and P. Ghibes and K. Nikolaou$^*$ and C. la
                      Fougère$^*$ and H. Dittmann},
      title        = {{N}on-invasive estimation of split renal function from
                      routine 68{G}a-{SSR}-{PET}/{CT} scans.},
      journal      = {Frontiers in medicine},
      volume       = {10},
      issn         = {2296-858X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2023-01443},
      pages        = {1169451},
      year         = {2023},
      abstract     = {Patients with impaired kidney function are at elevated risk
                      for nephrotoxicity and hematotoxicity from peptide receptor
                      radionuclide therapy (PPRT) for advanced neuroendocrine
                      tumors. Somatostatin receptor (SSR)-PET/CT imaging is the
                      method of choice to identify sufficient SSR expression as a
                      prerequisite for PRRT. Therefore, our study aimed to explore
                      whether split renal function could be evaluated using
                      imaging data from routine SSR-PET/CT prior to PRRT.In total,
                      25 consecutive patients who underwent SSR-PET/CT (Siemens
                      Biograph mCT®) before PRRT between June 2019 and December
                      2020 were enrolled in this retrospective study. PET
                      acquisition in the caudocranial direction started at 20 ±
                      0.5 min after an i.v. injection of 173 ± 20 MBq [68Ga]Ga-ha
                      DOTATATE, and the kidneys were scanned at 32 ± 0.5 min p.i.
                      The renal parenchyma was segmented semi-automatically using
                      an SUV-based isocontour (SUV between 5 and 15). Multiple
                      parameters including SUVmean of renal parenchyma and blood
                      pool, as well as parenchyma volume, were extracted, and
                      accumulation index (ACI: renal parenchyma volume/SUVmean)
                      and total kidney accumulation (TKA: SUVmean x renal
                      parenchyma volume) were calculated. All data were correlated
                      with the reference standard tubular extraction rate
                      (TER-MAG) from [99mTc]Tc-MAG3 scintigraphy and glomerular
                      filtration rate (GFRCDK - EPI).SUVmean of the parenchymal
                      tracer retention showed a negative correlation with TERMAG
                      (r: -0.519, p < 0.001) and GFRCDK - EPI (r: -0.555, p <
                      0.001) at 32 min p.i. The herein-introduced ACI revealed a
                      significant correlation (p < 0.05) with the total tubular
                      function (r: 0.482), glomerular renal function (r: 0.461),
                      split renal function (r: 0.916), and absolute single-sided
                      renal function (r: 0.549). The mean difference between the
                      split renal function determined by renal scintigraphy and
                      ACI was 1.8 ± 4.2 $\%$ points.This pilot study indicates
                      that static [68Ga]Ga-ha DOTATATE PET-scans at 32 min p.i.
                      may be used to estimate both split renal function and
                      absolute renal function using the herein proposed
                      'Accumulation Index' (ACI).},
      keywords     = {DOTATATE (Other) / NET (neuro-endocrinal tumors) (Other) /
                      PRRT (peptide receptor radionuclide therapy) (Other) / SSR
                      PET/CT (Other) / accumulation index (Other) / single-sided
                      renal function (Other) / split renal function (Other) /
                      total kidney accumulation (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37448797},
      pmc          = {pmc:PMC10337782},
      doi          = {10.3389/fmed.2023.1169451},
      url          = {https://inrepo02.dkfz.de/record/277726},
}