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@ARTICLE{Safizadeh:277732,
      author       = {F. Safizadeh$^*$ and M. Mandic$^*$ and D. Pulte$^*$ and T.
                      Niedermaier$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{T}he underestimated impact of excess body weight on
                      colorectal cancer risk: {E}vidence from the {UK} {B}iobank
                      cohort.},
      journal      = {British journal of cancer},
      volume       = {129},
      number       = {5},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-01449},
      pages        = {829-837},
      year         = {2023},
      note         = {#EA:C070#LA:C070#LA:C120# / 2023 Sep;129(5):829-837},
      abstract     = {The association between excess weight and colorectal cancer
                      (CRC) risk may have been underestimated due to potential
                      weight loss during pre-clinical sojourn time of CRC. We
                      aimed to investigate this association and the corresponding
                      population attributable fraction (PAF), accounting for
                      prediagnostic weight loss.Data from the UK Biobank
                      prospective cohort were used. Multivariable adjusted hazard
                      ratios (HR) and their $95\%$ confidence intervals (CI) for
                      various periods of follow-up and the corresponding PAF of
                      excess weight were calculated.During a median of 10.0 years
                      of follow-up, of 453,049 participants, 4794 developed CRC.
                      The excess weight-CRC association became substantially
                      stronger with including increasing lengths of follow-up in
                      the analyses and further excluding the initial years of
                      follow-up. HRs $(95\%$ CIs) for overweight and obesity were
                      1.06 (0.97-1.16) and 1.14 (1.03-1.26) after 7 years of
                      follow-up, 1.13 (1.05-1.21) and 1.23 (1.14-1.33) when
                      including complete follow-up length, and 1.26 (1.12-1.43)
                      and 1.42 (1.24-1.63) when excluding the initial 7 years of
                      follow-up. The corresponding PAFs of excess weight were
                      estimated as $6.8\%,$ $11.3\%,$ and $19.0\%,$
                      respectively.Comprehensive consideration of the potential
                      effect of prediagnostic weight loss discloses a much
                      stronger impact of excess body weight on CRC risk than
                      previously assumed.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37443347},
      doi          = {10.1038/s41416-023-02351-6},
      url          = {https://inrepo02.dkfz.de/record/277732},
}