TY  - JOUR
AU  - Spautz, Saskia
AU  - Haase, Leon
AU  - Tschiche, Maria
AU  - Makocki, Sebastian
AU  - Richter, Christian
AU  - Troost, Esther G C
AU  - Stützer, Kristin
TI  - Comparison of 3D and 4D robustly optimized proton treatment plans for non-small cell lung cancer patients with tumour motion amplitudes larger than 5 mm.
JO  - Physics & Imaging in Radiation Oncology
VL  - 27
SN  - 2405-6316
CY  - Amsterdam [u. a.]
PB  - Elsevier Science
M1  - DKFZ-2023-01454
SP  - 100465
PY  - 2023
AB  - There is no consensus about an ideal robust optimization (RO) strategy for proton therapy of targets with large intrafractional motion. We investigated the plan robustness of 3D and different 4D RO strategies.For eight non-small cell lung cancer patients with clinical target volume (CTV) motion >5 mm, different RO approaches were investigated: 3DRO considering the average CT (AvgCT) with a target density override, 4DRO considering three/all 4DCT phases, and 4DRO considering the AvgCT and three/all 4DCT phases. Robustness against setup/range errors, interplay effects based on breathing and machine log file data for deliveries with/without rescanning, and interfractional anatomical changes were analyzed for target coverage and OAR sparing.All nominal plans fulfilled the clinical requirements with individual CTV coverage differences <2pp; 4DRO without AvgCT generated the most conformal dose distributions. Robustness against setup/range errors was best for 4DRO with AvgCT (18
KW  - Interfraction changes (Other)
KW  - Large intrafraction motion (Other)
KW  - Lung cancer (Other)
KW  - Proton therapy (Other)
KW  - Robust optimization (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37449022
C2  - pmc:PMC10338142
DO  - DOI:10.1016/j.phro.2023.100465
UR  - https://inrepo02.dkfz.de/record/277737
ER  -