TY  - JOUR
AU  - Veltsista, Paraskevi Danai
AU  - Oberacker, Eva
AU  - Ademaj, Adela
AU  - Corradini, Stefanie
AU  - Eckert, Franziska
AU  - Flörcken, Anne
AU  - Kaul, David
AU  - Lindner, Lars H
AU  - Issels, Rolf
AU  - Ott, Oliver J
AU  - Pink, Daniel
AU  - Potkrajcic, Vlatko
AU  - Reichardt, Peter
AU  - Roohani, Siyer
AU  - Spalek, Mateusz Jacek
AU  - Riesterer, Oliver
AU  - Zips, Daniel
AU  - Ghadjar, Pirus
TI  - Hyperthermia in the treatment of high-risk soft tissue sarcomas: a systematic review.
JO  - International journal of hyperthermia and thermal therapies
VL  - 40
IS  - 1
SN  - 0265-6736
CY  - London
PB  - Informa UK Limited
M1  - DKFZ-2023-01477
SP  - 2236337
PY  - 2023
AB  - The therapy of high-risk soft tissue sarcomas (STS) remains an interdisciplinary challenge. Regional hyperthermia (RHT) sparked interest as it has been shown to improve overall survival when added to perioperative chemotherapy (CTX). However, questions arise on how RHT should be optimally integrated into current multi-modal therapies.We performed a systematic literature review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies written in English and focused mainly on radiative RHT and superficial hyperthermia were evaluated and included. Studies including patients below the age of 18, with metastatic disease or review articles, were excluded.We identified 15 clinical reports from 1990 until July 2022. Three articles combined RHT + CTX, and twelve focused on combined RHT + radiotherapy (RT) or neoadjuvant chemoradiotherapy (CRT). Most treatments were based on invasive thermometry, and less on magnetic resonance imaging (MRI)-based, noninvasive thermometry for STS of the extremities. Perioperative chemotherapy was used for the combination of RHT and CTX, mostly Ifosfamide-based. The effectiveness of RT appeared to be increased by RHT, especially with two RHT sessions/week. The trimodal simultaneous approach of neoadjuvant RHT and CRT was also feasible. No significant toxicity of RHT was reported.The gathered data strengthen the beneficial role of RHT in the multimodal setting. Further expert consensus and clinical trials are required to determine the optimal integration of RHT in treating STS.
KW  - Humans
KW  - Hyperthermia, Induced: methods
KW  - Antineoplastic Combined Chemotherapy Protocols: therapeutic use
KW  - Sarcoma: therapy
KW  - Ifosfamide: therapeutic use
KW  - Combined Modality Therapy
KW  - Soft Tissue Neoplasms: drug therapy
KW  - Hyperthermia (Other)
KW  - chemotherapy (Other)
KW  - high-risk (Other)
KW  - radiation (Other)
KW  - sarcoma (Other)
KW  - Ifosfamide (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37468132
DO  - DOI:10.1080/02656736.2023.2236337
UR  - https://inrepo02.dkfz.de/record/277760
ER  -