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@ARTICLE{Veltsista:277760,
      author       = {P. D. Veltsista and E. Oberacker and A. Ademaj and S.
                      Corradini and F. Eckert and A. Flörcken and D. Kaul$^*$ and
                      L. H. Lindner and R. Issels and O. J. Ott and D. Pink and V.
                      Potkrajcic and P. Reichardt and S. Roohani$^*$ and M. J.
                      Spalek and O. Riesterer and D. Zips$^*$ and P. Ghadjar},
      title        = {{H}yperthermia in the treatment of high-risk soft tissue
                      sarcomas: a systematic review.},
      journal      = {International journal of hyperthermia and thermal
                      therapies},
      volume       = {40},
      number       = {1},
      issn         = {0265-6736},
      address      = {London},
      publisher    = {Informa UK Limited},
      reportid     = {DKFZ-2023-01477},
      pages        = {2236337},
      year         = {2023},
      abstract     = {The therapy of high-risk soft tissue sarcomas (STS) remains
                      an interdisciplinary challenge. Regional hyperthermia (RHT)
                      sparked interest as it has been shown to improve overall
                      survival when added to perioperative chemotherapy (CTX).
                      However, questions arise on how RHT should be optimally
                      integrated into current multi-modal therapies.We performed a
                      systematic literature review according to Preferred
                      Reporting Items for Systematic Reviews and Meta-Analyses
                      (PRISMA) guidelines. Studies written in English and focused
                      mainly on radiative RHT and superficial hyperthermia were
                      evaluated and included. Studies including patients below the
                      age of 18, with metastatic disease or review articles, were
                      excluded.We identified 15 clinical reports from 1990 until
                      July 2022. Three articles combined RHT + CTX, and twelve
                      focused on combined RHT + radiotherapy (RT) or neoadjuvant
                      chemoradiotherapy (CRT). Most treatments were based on
                      invasive thermometry, and less on magnetic resonance imaging
                      (MRI)-based, noninvasive thermometry for STS of the
                      extremities. Perioperative chemotherapy was used for the
                      combination of RHT and CTX, mostly Ifosfamide-based. The
                      effectiveness of RT appeared to be increased by RHT,
                      especially with two RHT sessions/week. The trimodal
                      simultaneous approach of neoadjuvant RHT and CRT was also
                      feasible. No significant toxicity of RHT was reported.The
                      gathered data strengthen the beneficial role of RHT in the
                      multimodal setting. Further expert consensus and clinical
                      trials are required to determine the optimal integration of
                      RHT in treating STS.},
      subtyp        = {Review Article},
      keywords     = {Humans / Hyperthermia, Induced: methods / Antineoplastic
                      Combined Chemotherapy Protocols: therapeutic use / Sarcoma:
                      therapy / Ifosfamide: therapeutic use / Combined Modality
                      Therapy / Soft Tissue Neoplasms: drug therapy / Hyperthermia
                      (Other) / chemotherapy (Other) / high-risk (Other) /
                      radiation (Other) / sarcoma (Other) / Ifosfamide (NLM
                      Chemicals)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37468132},
      doi          = {10.1080/02656736.2023.2236337},
      url          = {https://inrepo02.dkfz.de/record/277760},
}