TY  - JOUR
AU  - Lodde, Georg C
AU  - Hassel, Jessica
AU  - Wulfken, Lena M
AU  - Meier, Friedegund
AU  - Mohr, Peter
AU  - Kähler, Katharina
AU  - Hauschild, Axel
AU  - Schilling, Bastian
AU  - Loquai, Carmen
AU  - Berking, Carola
AU  - Hüning, Svea
AU  - Eckardt, Julia
AU  - Gutzmer, Ralf
AU  - Reinhardt, Lydia
AU  - Glutsch, Valerie
AU  - Nikfarjam, Ulrike
AU  - Erdmann, Michael
AU  - Beckmann, Catharina L
AU  - Stang, Andreas
AU  - Kowall, Bernd
AU  - Galetzka, Wolfgang
AU  - Roesch, Alexander
AU  - Ugurel, Selma
AU  - Zimmer, Lisa
AU  - Schadendorf, Dirk
AU  - Forschner, Andrea
AU  - Livingstone, Elisabeth
TI  - Adjuvant treatment and outcome of stage III melanoma patients: Results of a multicenter real-world German Dermatologic Cooperative Oncology Group (DeCOG) study.
JO  - European journal of cancer
VL  - 191
SN  - 0014-2964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01494
SP  - 112957
PY  - 2023
AB  - Clinical trials demonstrated significantly improved recurrence-free survival (RFS) of melanoma patients receiving adjuvant treatment. As data from controlled trials are based on selected populations, we investigated adjuvantly treated stage III melanoma patients under real-world conditions.In a prior multicenter cohort study, stage III-IV melanoma patients were analysed for their choice of adjuvant therapy. In this follow-up study, we examined RFS, overall and melanoma-specific survival (MSS) and response to the subsequent treatment of 589 stage III patients (232 BRAF-mutated) receiving adjuvant PD-1 inhibitors (PD1; n = 479) or targeted therapy (TT; n = 110).The median follow-up of the total cohort was 25.7 months. The main reason for premature discontinuation of adjuvant therapy was disease progression in PD1- (28.8
KW  - Adjuvant treatment (Other)
KW  - BRAF (Other)
KW  - Immunotherapy (Other)
KW  - Melanoma (Other)
KW  - PD1 (Other)
KW  - Real-world (Other)
KW  - Targeted therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37487400
DO  - DOI:10.1016/j.ejca.2023.112957
UR  - https://inrepo02.dkfz.de/record/277779
ER  -