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@ARTICLE{Mhl:277809,
      author       = {A. Möhl and S. Behrens$^*$ and F. Flaßkamp and N. Obi and
                      A. Kreienbrinck and B. Holleczek and K. Gali and J.
                      Chang-Claude$^*$ and H. Becher},
      title        = {{T}he impact of cardiovascular disease on all-cause and
                      cancer mortality: results from a 16-year follow-up of a
                      {G}erman breast cancer case-control study.},
      journal      = {Breast cancer research},
      volume       = {25},
      number       = {1},
      issn         = {1465-5411},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2023-01520},
      pages        = {89},
      year         = {2023},
      abstract     = {Cardiovascular disease (CVD) is the leading cause of death
                      worldwide. The aim of this study was to examine if CVD
                      affects the mortality of women after a breast cancer
                      diagnosis and population controls differently.The analysis
                      included a total of 3,555 women, diagnosed with primary
                      stage 1-3 breast cancer or in situ carcinoma between 2002
                      and 2005 and 7,334 controls breast cancer-free at
                      recruitment, all aged 50-74 years, who were followed-up in a
                      German breast cancer case-control study until June, 30 2020.
                      Kaplan-Meier and cumulative incidence function were
                      calculated for all-cause mortality and mortality from any
                      cancer, stratified for case-control status and CVD,
                      separately for women aged < 65 and ≥ 65 years. Cox
                      regression and Fine-Gray subdistribution hazard models were
                      used to estimate hazard ratios (HR) and $95\%$ confidence
                      intervals $(95\%$ CI) for the association between
                      case-control-status, CVD and mortality from all causes/any
                      cancer.The median follow-up was 16.1 years. In total, 1,172
                      cases $(33.0\%)$ and 1,401 initial controls $(19.1\%)$ died.
                      CVD prevalence at recruitment was $15.2\%$ in cases and
                      controls. Cases with CVD had the highest and controls
                      without CVD the lowest mortality during the entire
                      observation period in both age groups (< 65 and ≥ 65
                      years). CVD was identified as a risk factor for all-cause
                      mortality in both cases and controls aged < 65 years (HR
                      1.22, $95\%CI$ 0.96-1.55 and HR 1.79, $95\%CI$ 1.43-2.24) as
                      well as at ages of ≥ 65 years (HR 1.44, $95\%CI$ 1.20-1.73
                      and HR 1.59, $95\%CI$ 1.37-1.83). A significant association
                      of CVD and cancer mortality was found only for cases aged
                      ≥ 65 years.CVD was significantly associated with all-cause
                      mortality of both cases and controls and CVD was identified
                      as a risk factor for cancer mortality of cases aged ≥ 65
                      years at recruitment. Therefore, attention should be paid on
                      monitoring and preventing CVD in breast cancer patients,
                      especially in those diagnosed at older ages.},
      keywords     = {Breast cancer (Other) / Cardiovascular disease (Other) /
                      Case–control study (Other) / Mortality (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37501086},
      doi          = {10.1186/s13058-023-01680-x},
      url          = {https://inrepo02.dkfz.de/record/277809},
}