TY  - JOUR
AU  - Stocker, Hannah
AU  - Trares, Kira
AU  - Beyer, Léon
AU  - Perna, Laura
AU  - Rujescu, Dan
AU  - Holleczek, Bernd
AU  - Beyreuther, Konrad
AU  - Gerwert, Klaus
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years.
JO  - Alzheimer's research & therapy
VL  - 15
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DKFZ-2023-01532
SP  - 129
PY  - 2023
N1  - #EA:C070#LA:C070#
AB  - In order to utilize polygenic risk scores (PRSs) for Alzheimer's disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined the association of APOE4 and various PRSs, based on training sets that utilized differing AD definitions, with incident AD and all-cause dementia (ACD) within 17 years, and with levels of phosphorylated tau181 (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) in blood. Secondarily, effect modification by APOE4 status and sex was examined.In this prospective, population-based cohort study and nested case-control study, 9,940 participants in Germany were enrolled between 2000 and 2002 by their general practitioners and followed for up to 17 years. Participants were included in this study if dementia status and genetic data were available. A subsample of participants additionally had measurements of P-tau181, NfL, and GFAP obtained from blood samples. Cox and logistic regression analyses were used to assess the association of genetic risk (APOE genotype and PRSnoAPOE) with incident ACD/AD and log-transformed blood levels of P-tau181, NfL, and GFAP.Five thousand seven hundred sixty-five participants (54
KW  - Alzheimer’s disease (Other)
KW  - Blood-biomarkers (Other)
KW  - Polygenic risk scores (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37516890
C2  - pmc:PMC10386275
DO  - DOI:10.1186/s13195-023-01277-8
UR  - https://inrepo02.dkfz.de/record/277864
ER  -