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@ARTICLE{Foskolou:277868,
      author       = {I. P. Foskolou and L. Bunse$^*$ and J. Van den Bossche},
      title        = {2-hydroxyglutarate rides the cancer-immunity cycle.},
      journal      = {Current opinion in biotechnology},
      volume       = {83},
      issn         = {0958-1669},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01536},
      pages        = {102976},
      year         = {2023},
      abstract     = {2-hydroxyglutarate (2HG) is a biproduct of the Krebs cycle,
                      which exists in a D- and L- enantiomer and is structurally
                      similar to α-ketoglutarate. Both 2HG enantiomers have been
                      described to accumulate in diverse cancer and immune cells
                      and can influence cell fate and function. While D-2HG was
                      originally considered as an 'oncometabolite' that aberrantly
                      builds up in certain cancers, it is becoming clear that it
                      also physiologically accumulates in immune cells and
                      regulates immune function. Conversely, L-2HG is considered
                      as an 'immunometabolite' due to its induction and regulatory
                      function in T cells, but it can also be induced in certain
                      cancers. Here, the authors review the effects of both 2HG
                      enantiomers on immune cells within the tumor
                      microenvironment.},
      subtyp        = {Review Article},
      cin          = {D170 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)D170-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37515937},
      doi          = {10.1016/j.copbio.2023.102976},
      url          = {https://inrepo02.dkfz.de/record/277868},
}