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@ARTICLE{Vanbilloen:277870,
      author       = {W. J. F. Vanbilloen and J. S. Rechberger and J. B. Anderson
                      and L. F. Nonnenbroich$^*$ and L. Zhang and D. J. Daniels},
      title        = {{N}anoparticle {S}trategies to {I}mprove the {D}elivery of
                      {A}nticancer {D}rugs across the {B}lood-{B}rain {B}arrier to
                      {T}reat {B}rain {T}umors.},
      journal      = {Pharmaceutics},
      volume       = {15},
      number       = {7},
      issn         = {1999-4923},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01538},
      pages        = {1804},
      year         = {2023},
      abstract     = {Primary brain and central nervous system (CNS) tumors are a
                      diverse group of neoplasms that occur within the brain and
                      spinal cord. Although significant advances in our
                      understanding of the intricate biological underpinnings of
                      CNS neoplasm tumorigenesis and progression have been made,
                      the translation of these discoveries into effective
                      therapies has been stymied by the unique challenges
                      presented by these tumors' exquisitely sensitive location
                      and the body's own defense mechanisms (e.g., the brain-CSF
                      barrier and blood-brain barrier), which normally protect the
                      CNS from toxic insult. These barriers effectively prevent
                      the delivery of therapeutics to the site of disease. To
                      overcome these obstacles, new methods for therapeutic
                      delivery are being developed, with one such approach being
                      the utilization of nanoparticles. Here, we will cover the
                      current state of the field with a particular focus on the
                      challenges posed by the BBB, the different nanoparticle
                      classes which are under development for targeted CNS tumor
                      therapeutics delivery, and strategies which have been
                      developed to bypass the BBB and enable effective
                      therapeutics delivery to the site of disease.},
      subtyp        = {Review Article},
      keywords     = {blood–brain barrier (Other) / brain tumor (Other) /
                      chemotherapy (Other) / drug delivery (Other) / extracellular
                      vesicle (Other) / glioma (Other) / liposome (Other) /
                      nanoparticle (Other) / targeted therapy (Other)},
      cin          = {B310 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B310-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37513992},
      pmc          = {pmc:PMC10383584},
      doi          = {10.3390/pharmaceutics15071804},
      url          = {https://inrepo02.dkfz.de/record/277870},
}