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@ARTICLE{Diehl:277875,
      author       = {C. D. Diehl$^*$ and F. A. Giordano and A.-L. Grosu and S.
                      Ille and K.-H. Kahl and J. Onken$^*$ and S. Rieken and G. R.
                      Sarria and E. Shiban and A. Wagner and J. Beck and S.
                      Brehmer and O. Ganslandt and M. Hamed and B. Meyer and M.
                      Münter and A. Raabe and V. Rohde and K. Schaller and D.
                      Schilling and M. Schneider and E. Sperk and C. Thomé and P.
                      Vajkoczy and H. Vatter and S. E. Combs$^*$},
      title        = {{O}pportunities and {A}lternatives of {M}odern {R}adiation
                      {O}ncology and {S}urgery for the {M}anagement of
                      {R}esectable {B}rain {M}etastases.},
      journal      = {Cancers},
      volume       = {15},
      number       = {14},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01543},
      pages        = {3670},
      year         = {2023},
      abstract     = {Postsurgical radiotherapy (RT) has been early proven to
                      prevent local tumor recurrence, initially performed with
                      whole brain RT (WBRT). Subsequent to disadvantageous
                      cognitive sequalae for the patient and the broad
                      distribution of modern linear accelerators, focal
                      irradiation of the tumor has omitted WBRT in most cases. In
                      many studies, the effectiveness of local RT of the resection
                      cavity, either as single-fraction stereotactic radiosurgery
                      (SRS) or hypo-fractionated stereotactic RT (hFSRT), has been
                      demonstrated to be effective and safe. However, whereas
                      prospective high-level incidence is still lacking on which
                      dose and fractionation scheme is the best choice for the
                      patient, further ablative techniques have come into play.
                      Neoadjuvant SRS (N-SRS) prior to resection combines
                      straightforward target delineation with an accelerated
                      post-surgical phase, allowing an earlier start of systemic
                      treatment or rehabilitation as indicated. In addition,
                      low-energy intraoperative RT (IORT) on the surgical bed has
                      been introduced as another alternative to external beam RT,
                      offering sterilization of the cavity surface with steep dose
                      gradients towards the healthy brain. This consensus paper
                      summarizes current local treatment strategies for resectable
                      brain metastases regarding available data and
                      patient-centered decision-making.},
      subtyp        = {Review Article},
      keywords     = {brain metastases (Other) / intraoperative radiation therapy
                      (Other) / microsurgical resection (Other) / neurosurgery
                      (Other) / radiosurgery (Other) / stereotactic radiation
                      therapy (Other) / whole brain radiation therapy (Other)},
      cin          = {MU01 / BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331 / I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37509330},
      pmc          = {pmc:PMC10377800},
      doi          = {10.3390/cancers15143670},
      url          = {https://inrepo02.dkfz.de/record/277875},
}