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@ARTICLE{Liang:277876,
      author       = {C. Liang and J. Sekler and B. Gückel and C. Pfannenberg
                      and H. Dittmann and F. Seith and B. Amend and K.
                      Nikolaou$^*$ and C. P. Reinert},
      title        = {{H}ow [18{F}]-{FDG}-{PET}/{CT} {A}ffects {C}linical
                      {M}anagement of {P}atients with {G}erm {C}ell {T}umors in
                      the {R}eal {W}orld.},
      journal      = {Cancers},
      volume       = {15},
      number       = {14},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01544},
      pages        = {3652},
      year         = {2023},
      abstract     = {The aim of this study was to evaluate the impact of PET/CT
                      on clinical management of patients with germ cell tumors
                      (GCTs) conducted in a real-world setting, including
                      avoidance of invasive procedures, additional diagnostic
                      imaging, and changes in treatment.Patients with GCTs were
                      prospectively enrolled into a PET/CT registry study between
                      May 2013 and April 2021. Intended patient management prior
                      and after PET/CT was documented using standardized
                      questionnaires. Changes in oncologic staging and clinical
                      management after PET/CT were recorded, including planned
                      treatment and planned additional diagnostics.Forty-three
                      male patients with GCTs were included consecutively in this
                      study. After PET/CT, oncologic staging changed in 22/43
                      patients $(51\%),$ with upstaging in seven cases $(16\%),$
                      downstaging in ten cases $(23\%),$ and cancer relapse in
                      five cases $(11\%).$ The number of patients with intended
                      curative treatment remained stable, while a considerable
                      change in intended therapeutic intervention was noted after
                      PET/CT, with an increase in planned chemotherapy from three
                      to eleven patients and a decrease in planned surgical
                      resection from eleven to two patients. In addition, PET/CT
                      contributed to preventing patients from intended invasive
                      procedures including biopsy and surgery in 8/43 $(19\%)$
                      cases and from additional diagnostic procedures in 25
                      $(58\%)$ cases.With the use of FDG-PET/CT as a tool to guide
                      patient management in GCTs, we observed a notable impact on
                      clinical staging and a consequent reduction in the need for
                      additional invasive and diagnostic procedures. These
                      findings are expected to be even more consequential in the
                      future as treatment modalities improve and the life
                      expectancy of GCT patients further increases.PET/CT
                      considerably influences the clinical stage of GCT patients.
                      PET/CT has remarkable influence on the choice of therapeutic
                      interventions and reduces additional diagnostic procedures.},
      keywords     = {PET/CT (Other) / clinical management (Other) / germ cell
                      tumors (Other) / seminoma (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37509313},
      pmc          = {pmc:PMC10377569},
      doi          = {10.3390/cancers15143652},
      url          = {https://inrepo02.dkfz.de/record/277876},
}