TY  - JOUR
AU  - White, Christine L
AU  - Kinross, Kathryn M
AU  - Buntine, Molly K
AU  - Rasouli, Elnaz
AU  - Strong, Robyn
AU  - Jones, Janelle M
AU  - Cain, Jason E
AU  - Sturm, Dominik
AU  - Sahm, Felix
AU  - Jones, David T W
AU  - Pfister, Stefan M
AU  - Robertson, Thomas
AU  - D'Arcy, Colleen
AU  - Rodriguez, Michael L
AU  - Dyke, Jason M
AU  - Junckerstorff, Reimar
AU  - Bhuva, Dharmesh D
AU  - Davis, Melissa J
AU  - Wood, Paul
AU  - Hassall, Tim
AU  - Ziegler, David S
AU  - Kellie, Stewart
AU  - McCowage, Geoffrey
AU  - Alvaro, Frank
AU  - Kirby, Maria
AU  - Heath, John A
AU  - Tsui, Karen
AU  - Dodgshun, Andrew
AU  - Eisenstat, David D
AU  - Khuong-Quang, Dong-Anh
AU  - Wall, Meaghan
AU  - Algar, Elizabeth M
AU  - Gottardo, Nicholas G
AU  - Hansford, Jordan R
TI  - Implementation of DNA methylation array profiling in pediatric central nervous system tumors - the AIM BRAIN Project: an Australian and New Zealand Children's Haematology and Oncology (ANZCHOG) Group study.
JO  - The journal of molecular diagnostics
VL  - 25
IS  - 10
SN  - 1525-1578
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01550
SP  - 709-728
PY  - 2023
N1  - 2023 Oct;25(10):709-728
AB  - DNA methylation array profiling for classifying pediatric central nervous system (CNS) tumors is a valuable adjunct to histopathology. However, unbiased prospective and inter-laboratory validation studies have been lacking. The AIM BRAIN (AB) diagnostic trial involving 11 pediatric cancer centers in Australia and New Zealand was designed to test the feasibility of routine clinical testing and ran in parallel with the Molecular Neuropathology 2.0 (MNP2.0) study at Deutsches Krebsforschungszentrum (DKFZ) (German Cancer Centre Heidelberg, Germany). CNS tumors from 269 pediatric patients were prospectively tested on Illumina EPIC arrays including 104 cases co-enrolled on MNP2.0. Using MNP classifier versions 11b4 and 12.5, we report classifications with a probability score ≥ 0.90 in 176/265 (66.4
LB  - PUB:(DE-HGF)16
C6  - pmid:37517472
DO  - DOI:10.1016/j.jmoldx.2023.06.013
UR  - https://inrepo02.dkfz.de/record/277882
ER  -