%0 Journal Article
%A Fleischhauer, Katharina
%A Tran, Thuong Hien
%A Meisel, Roland
%A Mytilineos, Joannis
%A Dreger, Peter
%A Kröger, Nicolaus
%T Donor Selection for Allogeneic Hematopoietic Cell Transplantation.
%J Deutsches Ärzteblatt international
%V 120
%N 15
%@ 1866-0452
%C Köln
%I Dt. Ärzte-Verl.
%M DKFZ-2023-01552
%P 261-268
%D 2023
%X In Germany, each year over 3000 patients with malignant and non-malignant hematologic and systemic diseases are treated by allo - geneic hematopoietic cell transplantation (HCT). Genetic donor-recipient disparities, especially those concerning variable human leukocyte antigens (HLA), mediate both an immunotherapeutic effect and the risk of damage to healthy tissues ('graft-versus-host disease'). The adoption of evidencebased strategies for donor selection has been crucial for the continuous improvement of survival rates after allogeneic HCT, with over 50
%K Humans
%K Donor Selection
%K Hematopoietic Stem Cell Transplantation
%K Graft vs Host Disease: prevention & control
%K Unrelated Donors
%K Leukemia, Myeloid, Acute
%K HLA Antigens
%K Retrospective Studies
%K HLA Antigens (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36949660
%2 pmc:PMC10366961
%R 10.3238/arztebl.m2023.0031
%U https://inrepo02.dkfz.de/record/277884