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@ARTICLE{Keshwani:277887,
      author       = {K. Keshwani and T. Boterberg and K. Dieckmann and G. O.
                      Janssens and A. Laprie and B. Timmermann$^*$ and M. N. Gaze},
      title        = {{R}adical skeletal metastatic site irradiation in high-risk
                      neuroblastoma: systematic review and proposal for a
                      randomised trial},
      journal      = {Journal of Cancer Metastasis and Treatment},
      volume       = {9},
      issn         = {2394-4722},
      address      = {Mumbai},
      publisher    = {Medknow},
      reportid     = {DKFZ-2023-01554},
      pages        = {A27},
      year         = {2023},
      abstract     = {Aim: Neuroblastoma has a variable outcome depending on age,
                      stage, and molecular pathology. Distant metastatic disease
                      is the central feature of high-risk disease. Recommendations
                      for irradiating persistent metastatic deposits with curative
                      intent after systemic therapy vary. It is unclear to what
                      extent this practice may improve local control or survival.
                      This study systematically reviewed the evidence for skeletal
                      metastatic site irradiation and made evidence-based
                      recommendations for clinical practice. Methods: We
                      systematically reviewed the literature on radical
                      radiotherapy of persistent metastases after chemotherapy.
                      The aim was to determine whether a position could be taken
                      regarding metastatic site irradiation in combined modality
                      treatment protocols aiming for a cure and whether
                      recommendations could be formulated Results: The initial
                      search yielded 445 results. After the title and abstract
                      review, 13 full papers were retrieved. Ten papers were found
                      suitable for data extraction. One additional paper was
                      identified. All 11 were graded as Centre for Evidence-Based
                      Medicine Step 4 in quality; there was no high-level
                      evidence. There are suggestions of benefit for skeletal site
                      irradiation in high-risk neuroblastoma; however, there is no
                      certainty, and it was not possible to recommend a particular
                      treatment policy. Conclusion: We recommend that
                      consideration is given to a randomised evaluation of the
                      benefits of radiotherapy to a limited number of residual
                      post-induction-chemotherapy metastatic sites in good
                      responders. This practice could be incorporated as an
                      amendment to existing trials.},
      subtyp        = {Review Article},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.20517/2394-4722.2022.32},
      url          = {https://inrepo02.dkfz.de/record/277887},
}