TY  - JOUR
AU  - Group, SCORE2-Diabetes Working
TI  - SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe.
JO  - European heart journal
VL  - 44
IS  - 28
SN  - 0195-668X
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2023-01555
SP  - 2544 - 2556
PY  - 2023
AB  - To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe.SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 460 participants (43 706 CVD events) with type 2 diabetes and without previous CVD. Sex-specific competing risk-adjusted models were used including conventional risk factors (i.e. age, smoking, systolic blood pressure, total, and HDL-cholesterol), as well as diabetes-related variables (i.e. age at diabetes diagnosis, glycated haemoglobin [HbA1c] and creatinine-based estimated glomerular filtration rate [eGFR]). Models were recalibrated to CVD incidence in four European risk regions. External validation included 217 036 further individuals (38 602 CVD events), and showed good discrimination, and improvement over SCORE2 (C-index change from 0.009 to 0.031). Regional calibration was satisfactory. SCORE2-Diabetes risk predictions varied several-fold, depending on individuals' levels of diabetes-related factors. For example, in the moderate-risk region, the estimated 10-year CVD risk was 11
KW  - Male
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - Diabetes Mellitus, Type 2: complications
KW  - Diabetes Mellitus, Type 2: epidemiology
KW  - Cardiovascular Diseases: epidemiology
KW  - Cardiovascular Diseases: etiology
KW  - Risk Factors
KW  - Glycated Hemoglobin
KW  - Europe: epidemiology
KW  - Heart Disease Risk Factors
KW  - Cardiovascular diseases (Other)
KW  - Diabetes (Other)
KW  - Prediction model (Other)
KW  - Glycated Hemoglobin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37247330
C2  - pmc:PMC10361012
DO  - DOI:10.1093/eurheartj/ehad260
UR  - https://inrepo02.dkfz.de/record/277888
ER  -