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@ARTICLE{Neumann:277914,
      author       = {B. Neumann and J. Onken and N. König and H. Stetefeld and
                      S. Luger and A.-L. Luger$^*$ and F. Schlachetzki and R.
                      Linker and P. Hau and E. Bumes},
      title        = {{O}utcome of glioblastoma patients after intensive care
                      unit admission with invasive mechanical ventilation: a
                      multicenter analysis.},
      journal      = {Journal of neuro-oncology},
      volume       = {164},
      number       = {1},
      issn         = {0167-594x},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DKFZ-2023-01573},
      pages        = {249-256},
      year         = {2023},
      note         = {2023 Aug;164(1):249-256},
      abstract     = {Patients with glioblastoma are exposed to severe symptoms
                      and organs failures (e.g., coma or acute respiratory
                      failure), that may require intensive care unit (ICU)
                      admission and invasive mechanical ventilation (IMV).
                      However, only limited data are available concerning the
                      prognosis of patients with glioblastoma receiving IMV. We
                      sought to describe the reasons for ICU admission, and
                      outcomes of patients with glioblastoma requiring IMV for
                      unplanned critical complications.In this retrospective
                      analysis, four certified interdisciplinary brain tumor
                      centers performed a retrospective review of their electronic
                      data systems. All patients with glioblastoma admitted to an
                      in-house ICU and receiving IMV between January 2015 and
                      December 2019 were included. Clinical and prognostic factors
                      as well as relevant outcome parameters were evaluated by
                      group comparisons and Kaplan Meier survival curves.We
                      identified 33 glioblastoma patients with a duration of IMV
                      of 9.2 ± 9.4 days. Main reasons for ICU admission were
                      infection (n = 12; $34.3\%)$ including 3 cases of
                      Pneumocystis jirovecii pneumonia, status epilepticus
                      $(31.4\%)$ and elevated intracranial pressure $(22.9\%).$
                      In-hospital mortality reached $60.6\%.$ Younger age, low
                      number of IMV days, better Karnofsky Performance Status
                      Scale before admission and elevated intracranial pressure as
                      cause of ICU admission were associated with positive
                      prognostic outcome.We conclude that less than $50\%$ of
                      patients with glioblastoma have a favorable short-term
                      outcome when unplanned ICU treatment with IMV is required.
                      Our data mandate a careful therapy guidance and frequent
                      reassessment of goals during ICU stay.},
      keywords     = {Glioblastoma (Other) / Intensive care unit (Other) /
                      Invasive mechanical ventilation (Other) / Outcome (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37530945},
      doi          = {10.1007/s11060-023-04403-6},
      url          = {https://inrepo02.dkfz.de/record/277914},
}