% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Park:277925,
      author       = {H. A. Park$^*$ and D. Edelmann$^*$ and F. Canzian$^*$ and
                      P. Seibold$^*$ and T. A. Harrison and X. Hua and Q. Shi and
                      A. Silverman and A. Benner$^*$ and A. Macauda$^*$ and M.
                      Schneider and R. M. Goldberg and S. R. Alberts and M.
                      Hoffmeister$^*$ and H. Brenner$^*$ and A. T. Chan and U.
                      Peters and P. A. Newcomb and J. Chang-Claude$^*$},
      title        = {{G}enome-wide study of genetic polymorphisms predictive for
                      outcome from first-line oxaliplatin-based chemotherapy in
                      colorectal cancer patients.},
      journal      = {International journal of cancer},
      volume       = {153},
      number       = {9},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-01581},
      pages        = {1623-1634},
      year         = {2023},
      note         = {#EA:C020#LA:C020# / 2023 Nov 1;153(9):1623-1634},
      abstract     = {We conducted the first large genome-wide association study
                      to identify novel genetic variants that predict better (or
                      poorer) prognosis in colorectal cancer patients receiving
                      standard first-line oxaliplatin-based chemotherapy vs
                      chemotherapy without oxaliplatin. We used data from two
                      phase III trials, NCCTG N0147 and NCCTG N9741 and a
                      population-based patient cohort, DACHS. Multivariable Cox
                      proportional hazards models were employed, including an
                      interaction term between each SNP and type of treatment for
                      overall survival (OS) and progression-free survival. The
                      analysis was performed for studies individually, and the
                      results were combined using fixed-effect meta-analyses
                      separately for resected stage III colon cancer (3098
                      patients from NCCTG N0147 and 549 patients from DACHS) and
                      mCRC (505 patients from NCCTG N9741 and 437 patients from
                      DACHS). We further performed gene-based analysis as well as
                      in silico bioinformatics analysis for CRC-relevant
                      functional genomic annotation of identified loci. In stage
                      III colon cancer patients, a locus on chr22 (rs11912167) was
                      associated with significantly poorer OS after
                      oxaliplatin-based chemotherapy vs chemotherapy without
                      oxaliplatin (Pinteraction < 5 × 10-8 ). For mCRC patients,
                      three loci on chr1 (rs1234556), chr12 (rs11052270) and chr15
                      (rs11858406) were found to be associated with differential
                      OS (P < 5 × 10-7 ). The locus on chr1 located in the
                      intronic region of RCSD1 was replicated in an independent
                      cohort of 586 mCRC patients from ALGB/SWOG 80405
                      (Pinteraction = .04). The GWA gene-based analysis yielded
                      for RCSD1 the most significant association with differential
                      OS in mCRC (P = 6.6 × 10-6 ). With further investigation
                      into its biological mechanisms, this finding could
                      potentially be used to individualize first-line treatment
                      and improve clinical outcomes.},
      keywords     = {adjuvant chemotherapy (Other) / colorectal cancer prognosis
                      (Other) / genome-wide association study (Other) /
                      oxaliplatin-based treatment (Other) / single nucleotide
                      polymorphism (Other)},
      cin          = {C020 / C060 / C055 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)C055-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37539667},
      doi          = {10.1002/ijc.34663},
      url          = {https://inrepo02.dkfz.de/record/277925},
}